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Applicability of sensitization testing methods for regulatory purposes

Start date: 2 Feb. 2010

End date: 3 Feb. 2010

Organised by Cefic LRI together with CESIOCES and EFfCI, the workshop is open to all stakeholders from industry sectors, academia, NGO’s and regulatory agencies.

The aim of this 1.5 day workshop is to:

– ensure a common understanding of the applicability of the current animal tests (OECD 429/LLNA and OECD 406/guinea pig tests),

– consolidate industry’s experience with these tests

– increase our awareness of the strengths and gaps of these test methods in order to optimize the process of developing future 3R’s methods in skin sensitization.

– help develop a flexible skin sensitization testing strategy in order to ensure reliable hazard identification and risk assessment across chemical classes.

More information and registration: http://www.workshop-sensitization-methods.org/

Click here to download the Final Report of the workshop.

AGENDA

DAY 1

– Welcome

J.C. Carrillo (CESIO/Cefic-LRI)

 

Session 1

Scope: Background on skin sensitization hazard identification

– Introduction to skin sensitization and tests for skin sensitization hazard identification

Ian Kimber (University of Manchester) & M. Woolhiser (CESIO)

 

– Aspects in the development of “in-vitro based alternatives for sensitization testing”

Matthias Peiser (BfR)

 

Session 2

Scope: The LLNA as the preferred method under REACH

– Comparative sensitization data from Industry based on LLNA and Guinea Pig testing

CESIO data – J.C. Carrillo/C. Garcia/N.Ball

EFfCI data – R. Kreiling

CES data – D. Eigler

 

– C&L framework, REACH “gold standard”; what does it imply?

N. Ball (CESIO)

 

DAY 2

Recap session

Scope: Summary of forum discussion of day 1 & outlook for day 2

J.C. Carrillo (CESIO/Cefic-LRI)

 

Session 3

Briefing on break-out groups

– Is there a single gold standard?

Vera Rogiers (VUB, University of Brussels)

 

– Applicability domain, what can we do about it?

D. Basketter (DABMEB Consultancy)

 

– The use of LLNA for the development of next generation tests

S. Casati (ECVAM)

 

Session 4

Report, conclusions and recommendations

– Conclusions: Is there a single gold standard?

Vera Rogiers (VUB, University of Brussels)

 

– Conclusions: Applicability, what can we do about it?

D. Basketter (DABMEB Consultancy)

 

– Conclusions: The use of LLNA for the development of next generation tests

S. Casati (ECVAM)

 

 

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