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External Useful Links

  • Understanding the effects of chemicals

On this section you will find a list of external links to testing methods, models and databases that can be used for risk assessment of chemicals for registration purposes. You can access the information by clicking on the titles of the toolkits.


1. ECHA Information Toolkit (eChem Portal)

This toolkit gives practical information and tools that help in using of existing information and non-test methods (i.e. predictions) as a first step to meeting REACH information requirements.


2. OECD Environmental Risk Assessment Toolkit

This toolkit gives access to practical tools on environmental risk assessment of chemicals. It describes the general work flow of environmental risk assessment and provides examples of risk assessment. This toolkit also provides links to relevant tools developed by OECD and member countries that can be used in each step of the work flow.


3. The OECD QSAR Toolbox

The Toolbox is a software application intended to be used by governments, chemical industry and other stakeholders in filling gaps in (eco)toxicity data needed for assessing the hazards of chemicals. The Toolbox incorporates information and tools from various sources into a logical workflow.


4. OpenTox

The OpenTox Framework provides tools for the integration of data from various sources (public and confidential), for the generation and validation of computer models for toxic effects, libraries for the development and seamless integration of new algorithms, and scientifically sound validation routines.


5. WHO Human Health Risk Assessment Toolkit: Chemical Hazards

The WHO Human Health Risk Assessment Toolkit: Chemical Hazards provides users with guidance to identify, acquire and use the information needed to assess chemical hazards, exposures and the corresponding health risks in their given health risk assessment contexts at local and/or national levels.

6. FP QSAR modeling tools: ANTARES

Before making an animal experiment the industry should verify if alternative methods exist. However, so far there is a deep gap of knowledge on which methods are available and can be used in practice. ANTARES aims to reduce the gap assessing non-testing methods (NTM) as an alternative approach for the REACH legislation.

7. ECVAM in-vitro DB

The DB-ALM is indicated by the European Chemicals Agency for REACH (REgistration, Authorisation and restriction of CHemicals, Regulation (EC) 1907/2006) for registration purposes as a useful information source on in vitro methods for consideration during information gap analysis or in a weight of evidence approach.

8. ECETOC Targeted Risk Assessment Tool

The ECETOC Targeted Risk Assessment (TRA) tool was launched in 2004 and consists of 3 separate models for estimating exposures to workers, consumers and the environment that arise during a series of events (‘exposure scenarios‘). The TRA Tool has had a major beneficial impact on REACH (Regulation on Registration, Evaluation, Authorisation and Restriction of Chemicals) since there was no other way chemical safety assessments (CSAs) could be compiled without it. More than 80% of the CSAs submitted in the first two rounds of REACH registrations have been based on the TRA. In the current version (3.1), ECETOC has further improved the consumer portion of the model by the inclusion of the ability to account for infrequent uses of consumer products. The changes which have been developed in cooperation with ECHA are also found within version 2.3 of Chesar (Link to Chesar website).






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