Cefic-lri Programme | European Chemical Industry Council

Complex environments

EMSG34.4-BACR: Continuation of the Hershberger validation with the intact weanling male rat to prove equivalence to the classic castrated male rat version

The current method of assessing the (anti-)androgenic potential of a compound in vivo is through the use of the Hershberger assay.  This involves first castrating adult male rats, allowing the sexual accessory tissues to regress and then exposing the rats […]

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EMSG39-BAHE: Assessment of biological variability in mice – Development of a draft protocol

The objectives of this project ar the following: Literature search on biological variability and evaluation with regard to organ weights, cylcicity, sperm parameters Drafting of pre- and main study for the assessment of biological variability

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EMSG43: Endocrine disrupting effects in fish induced by parasites

Recently evidence evolved that environmental compounds can interfere with the endocrine systems of wildlife and humans. Surface waters are suggested to be the main sink for these so called endocrine disruptors (ED). Therefore aquatic species seem to be the main […]

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EMSG47-WCA: Support a tiered approach to evaluate endocrine effects in aquatic organisms

The specific objectives of the project are: - Development of a ”Threshold of Toxicological Concern (TTC)” concept for ecotoxicology that is analogous to the mammalian approach. Potency, environmental fate and exposure to a substance should be considered to establish environmental […]

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EMSG49-CNRS: Reprogramming of DNA methylation during mammalian development and environmental impact of Endocrine Disruptors

The analysis of epigenetic modifications at the level of the genome is a very promising field of research. The major question to be addressed is how the epigenome distinguishes cell types and how epigenetic variability between individuals reflects the influence […]

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EMSG52-MRC: Steroidogenesis and inter species comparison literature review

Masculinisation depends on adequate production of testosterone by the fetal testis within a specific'male programming window'. Disorders resulting from subtle deficiencies in this process are common in humans and environmental exposures/lifestyle could contribute causally as common therapeutic and environmental compounds […]

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EMSG37-BAYER: Participation of Bayer CropScience in Phase 1A and 1B of the OECD validation work on the “Non-Spawning Fish Screening Assay” for the detection of endocrine active substances according to the OECD test protocol (ENV/JM/TG/EDTA(2002)5)

In a 21-day-assay (phase 1 B), sexually mature female and male fathead minnows (Pimephales promelas) were exposed to a weak estrogen agonist, or a weak aromatase inhibitor, under flow-through conditions. Three different test-compound concentrations, a water-only control, and a corresponding positive control […]

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EMSG54: Advancing Neurodevelopmental Evaluation in Children: An Interdisciplinary Scientific Approach

With published research suggesting growing numbers of children affected by an array of neurodevelopmental disorders, questions regarding etiology will continue to be raised. The uses of neurodevelopmental tests in studies of environmental chemicals and pediatric neurodevelopmental disorders have been reviewed […]

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EMSG46: Characterization of testicular toxicity using traditional and omic tools

The aim of this project is to characterize adult rat testicular toxicity induced by compounds that have either an estrogenic or a non-estrogenic mode of action. To fully realise this goal, the differentiation between normal background variability (ie no effect), […]

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HBM1-UCRA: A Framework for the Development and Application of Environmental Biological Monitoring Guidance Values

Biomonitoring is a useful tool to aid the assessment of exposure to many chemical substances but currently our ability to detect hazardous substances (or their metabolites and effects) may often exceed our understanding of the biological relevance of these results. […]

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