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Projects | Complex environments

EMSG34.4-SYNG: Evaluation of the weanling and testosterone-stimulateed weanling rat as an alternative to the Hershberger castrated rat in the detection of coded androgens and antiandrogens

Growing concerns regarding the possibility that environmental contaminants could mimic estrogens and androgens and hence disrupt endocrine systems have led to the evaluation of test systems to detect such contaminants. One system, the weanling rat assay, has been suggested as […]

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EMSG37-BAYER: Participation of Bayer CropScience in Phase 1A and 1B of the OECD validation work on the “Non-Spawning Fish Screening Assay” for the detection of endocrine active substances according to the OECD test protocol (ENV/JM/TG/EDTA(2002)5)

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In a 21-day-assay (phase 1 B), sexually mature female and male fathead minnows (Pimephales promelas) were exposed to a weak estrogen agonist, or a weak aromatase inhibitor, under flow-through conditions. Three different test-compound concentrations, a water-only control, and a corresponding positive control […]

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