Cefic-lri Programme | European Chemical Industry Council

Projects

EMSG58-MNEGRI: Human adverse health effects of endocrine active substances: assessment of the quality of individual epidemiological studies and of the overall mechanistic and epidemiologic evidence

The project's objective is to develop a systematic evaluation scheme to assess the quality and reliability of the epidemiological evidence for endocrine active substances to exert adverse effects based on an endocrine mode of action. This scheme is then to […]

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EMSG57-LAKIND: Endocrine disruptors and obesity, diabetes and heart disease: State of the science and biological plausibility

This project builds on (i) the lessons learned from the recently completed work on methodologic issues affecting epidemiologic research on BPA and (ii) the findings of the project (conducted under Cefic-LRI EMSG54) related to the importance of harmonization of epidemiologic methods for […]

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AIMT2-TNO: Mechanism-based characterisation of systemic toxicity for RepDose database substances employing in vitro toxicogenomics

Many in vitro toxicogenomics initatives so far focus on the overlap between in vitro mechanistic responses and in vivo toxicity, but are primarily concerned with mechanistic studies and hazard identification. Purpose of this study is to extend this towards applications of […]

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EMSG55-CEFAS: Critical evaluation of individual and combined natural and synthetic endocrine active compounds in fish: an in vitro & in vivo approach

The overall goal of this project is to characterize the potential in vitro and in vivo activities of plant-derived endocrine active compounds (EACs) versus synthetic substances and to evaluate potential combinatory effects of relevance to fish reproductive health. In particular, the […]

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EMSG56-BASF: Combined Low-dose Exposures to Anti-androgenic Substances

Considering the available definitions of endocrine disrupting compounds (Weybridge, 1996 and WHO/IPCS, 2002) it is recommended to follow an appropriate experimental design, duration of exposure, and completeness of relevant endpoints (OECD, 2002). As expected human exposures to chemicals, pesticides, biocides, […]

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EMSG34.4-SYNG: Evaluation of the weanling and testosterone-stimulateed weanling rat as an alternative to the Hershberger castrated rat in the detection of coded androgens and antiandrogens

Growing concerns regarding the possibility that environmental contaminants could mimic estrogens and androgens and hence disrupt endocrine systems have led to the evaluation of test systems to detect such contaminants. One system, the weanling rat assay, has been suggested as […]

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EMSG34.4-BACR: Continuation of the Hershberger validation with the intact weanling male rat to prove equivalence to the classic castrated male rat version

The current method of assessing the (anti-)androgenic potential of a compound in vivo is through the use of the Hershberger assay.  This involves first castrating adult male rats, allowing the sexual accessory tissues to regress and then exposing the rats […]

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EMSG39-BAHE: Assessment of biological variability in mice – Development of a draft protocol

The objectives of this project ar the following: Literature search on biological variability and evaluation with regard to organ weights, cylcicity, sperm parameters Drafting of pre- and main study for the assessment of biological variability

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EMSG49-CNRS: Reprogramming of DNA methylation during mammalian development and environmental impact of Endocrine Disruptors

The analysis of epigenetic modifications at the level of the genome is a very promising field of research. The major question to be addressed is how the epigenome distinguishes cell types and how epigenetic variability between individuals reflects the influence […]

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EMSG52-MRC: Steroidogenesis and inter species comparison literature review

Masculinisation depends on adequate production of testosterone by the fetal testis within a specific'male programming window'. Disorders resulting from subtle deficiencies in this process are common in humans and environmental exposures/lifestyle could contribute causally as common therapeutic and environmental compounds […]

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