Cefic-lri Programme | European Chemical Industry Council

Complex environments

EMSG49-CNRS: Reprogramming of DNA methylation during mammalian development and environmental impact of Endocrine Disruptors

The analysis of epigenetic modifications at the level of the genome is a very promising field of research. The major question to be addressed is how the epigenome distinguishes cell types and how epigenetic variability between individuals reflects the influence […]

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EMSG52-MRC: Steroidogenesis and inter species comparison literature review

Masculinisation depends on adequate production of testosterone by the fetal testis within a specific'male programming window'. Disorders resulting from subtle deficiencies in this process are common in humans and environmental exposures/lifestyle could contribute causally as common therapeutic and environmental compounds […]

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EMSG37-BAYER: Participation of Bayer CropScience in Phase 1A and 1B of the OECD validation work on the “Non-Spawning Fish Screening Assay” for the detection of endocrine active substances according to the OECD test protocol (ENV/JM/TG/EDTA(2002)5)

In a 21-day-assay (phase 1 B), sexually mature female and male fathead minnows (Pimephales promelas) were exposed to a weak estrogen agonist, or a weak aromatase inhibitor, under flow-through conditions. Three different test-compound concentrations, a water-only control, and a corresponding positive control […]

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EMSG54: Advancing Neurodevelopmental Evaluation in Children: An Interdisciplinary Scientific Approach

With published research suggesting growing numbers of children affected by an array of neurodevelopmental disorders, questions regarding etiology will continue to be raised. The uses of neurodevelopmental tests in studies of environmental chemicals and pediatric neurodevelopmental disorders have been reviewed […]

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EMSG46: Characterization of testicular toxicity using traditional and omic tools

The aim of this project is to characterize adult rat testicular toxicity induced by compounds that have either an estrogenic or a non-estrogenic mode of action. To fully realise this goal, the differentiation between normal background variability (ie no effect), […]

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HBM1-UCRA: A Framework for the Development and Application of Environmental Biological Monitoring Guidance Values

Biomonitoring is a useful tool to aid the assessment of exposure to many chemical substances but currently our ability to detect hazardous substances (or their metabolites and effects) may often exceed our understanding of the biological relevance of these results. […]

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EMSG44: Impact of physiological, lifestyle and environmental factors on the development of puberty

Puberty is the transitional period from childhood to adulthood. At puberty onset, a change in the set point (sensitivity) of the so-called ”gonadostat”, which is located in the hypothalamus, occurs. During childhood, small amounts of sex hormones produced in steroid […]

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B6-DOW: Improved hazard assessment of chemical sensitizers through testing of novel markers

The specific objectives of this project are as follows: - to provide genome-wide maps of kinetic changes in gene expression induced in draining lymph nodes following exposure of mice to a panel of selected chemicals (comprising chemicals known to cause […]

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CC3-ICL: Assessment of risk factors influencing trends in incidence of female breast carcinoma

There is a large body of literature published in peer-reviewed journals that report risk factors for breast cancer. Whilst studies continue to be reported that provide further evidence of an association between breast cancer incidence and established causal agents related […]

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B5-CERTH: Realistic estimation of exposure to substances from multiple sources (TAGS)

Exposure to chemical agents originates either from environmental contamination (air, water), or from consumer products (food contact materials, construction materials, cosmetics, clothes, etc.) through multiple routes, namely inhalation, ingestion and dermal contact. Aggregate exposure, i.e. the quantitative exposure assessment to […]

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