Cefic-lri Programme | European Chemical Industry Council

Projects

CC1-USTR: Interspecies Differences in the Metabolism of Toxic Aldehydes and Ketones by the AKR7 Family of Aldo-Keto Reductases

Highly reactive carbonyl compounds, aldehydes and ketones - found in a diverse range of natural and synthetic compounds - can cause cancer by damaging cell proteins and DNA. To help prevent this cells contain enzymes, which can break down these […]

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C1.6: Possibilities and capabilities of 3D-body-scanning systems for the purpose of risk assessment.

The result of this study shows that a vast pool of data is available from the many kinds of measurement surveys that have been carried out using 3D body scanner technology. However, to evaluate the data or to derive the […]

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EMSG22: Endocrine Disruption in the Aquatic Environment; Laboratory Investigation of Endocrine-Active Chemicals

Laboratory studies are being conducted in which fish are exposed to defined concentrations of known chemicals. Natural steroids, synthetic steroids and xenoestrogens will be assessed. The choice of test chemicals will depend on field studies in the UK and Germany, […]

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EMSG19: Chemicals and Pregnancy Study-UK (CHAPS-UK): Multicentre Study of Occupational Exposure to Chemicals and Male Fertility

The research institutes will study 6000 men attending any of the 10 fertility clinics in the UK over a period of 2 years. They will be classified as either fertile or infertile on the basis of sperm parameters. Standardised methods […]

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CC2-LUMC: Gene Expression Profiling in DNA Repair-Deficient XPA Transgenic Mice Following Treatment With Benzo[A]Pyrene and Cyclosporin-A: Lymphomagens with Different Modes of Action

Many environmental chemicals which have been shown to cause cancer in rodents have been implicated in human cancer. However, establishing cause and effect in humans is often impossible. Today, the only accepted test for human carcinogenicity is the two-year rodent […]

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D1.1-NOFE: Biomarkers of Exposure – Trends and Key Developments

The aim of the study was to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study encompassed […]

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EMSG23: Endocrine Modulating Effects in Fish Along the Elbe River and in Reference Areas. Assessment of Risks Related to the Habitat Conditions and the Natural Variability of Endocrine Functions

The aim of the study is to identify effects caused by endocrine modulation in fish and evaluate these with respect to dysfunction in sex differentiation, development of functional organs as well as fecundity. Another aspect is the determination of the […]

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EMSG20: Environmental Factors and Male Reproductive Functions. A Cohort Study of the Incidence of Cryptorchidism and Hypospadia in 5000 Newborn Boys in the Rotterdam Area

This is a study of 10,000 men, their (pregnant) partners and their new-born children. Information will be collected on the incidence of urogenital disorders such as Cryptorchidism, Hypospadia, lifestyle, working conditions of the male partner and time to pregnancy. The […]

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CC2-MRCT: Gene Expression Profiling of Skin Carcinogenesis in Mice Using cDNA Microarrays

Skin cancers are very common in humans - with around one million cases/year in the US - and their development can be affected by stimulators of growth such as certain chemicals. Although initiation is clearly extremely important, clonal expansion (promotion) […]

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IA4.6: A Rat IGE Test for the Identification of Chemical Respiratory Allergens

Some chemicals can induce allergies, including allergy of the lungs and other parts of the respiratory tract. (Examples include acid anhydrides, certain diisocyanates, some platinum salts, certain reactive dyes and plicatic acid). This is an important occupational health problem because […]

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