Cefic-lri Programme | European Chemical Industry Council

Complex environments

EMSG12: Exposure to Endocrine-Disruptor Chemicals Assessed by Ligand-Receptor Interaction Analysis of Human Body Fluids

The objective of the research was to determine whether the levels of binding between oestrogenic chemicals and pure oestrogen receptor could be quantified in vitro using ligand receptor interaction analysis. The hope was that such technology might be usefully applied […]

Read more

CC2-001-UWSW: Dose Relationships of DNA Adducts and Mutations

The common current assumption is that there is an essentially linear relationship between exposure to genotoxic chemicals, DNA lesion formation and the induction of mutagenic changes. A number of studies of DNA adduct induction indicate that such a linear relationship […]

Read more

A2.1: Literature Survey On Dermal Deposition In The Chemical Industry

Making reliable estimates of the amounts of chemicals deposited on the skin and clothing in the workplace is essential in evaluating any health risks. It also helps in assessing the effectiveness of protective equipment. There is a lack of detailed […]

Read more

EMSG16: Epidemiological Studies of Endocrine Disruptors and Human Health

Hypospadias is a male birth defect in which the urethral orifice is abnormally located on the ventral side of the penis. In western countries, the prevalence of hypospadias varies from 2 to 8 cases per 1000 live births. An increase […]

Read more

CC2-001-FSBW: Evaluation of Chemically-Induced Genotoxicity as an Increment to Background DNA Damage and Spontaneous Mutagenesis

DNA adducts are biomarkers of genotoxicity, and there is an ongoing discussion whether the dose response for DNA-adduct levels also predicts the dose response for mutation or even cancer. A linear low dose-effect relationship is plausible for the rate of […]

Read more

IRTA2-002-UUIR: Heterogeneity in Response to Iso-Cyanate Exposure in the Work Environment

Di-isocyanates are in many countries a major cause of occupational asthma. However, few recent studies are available in which exposure to isocyanates has been measured and related to respiratory disease risk. Thus, information about exposure response relationships is extremely limited. […]

Read more

EMSG17: Identification of Biomedical Endpoints of Oestrogen Action in the Male Rat With Possible Confirmation in Primate Model and in Man

The objective of the project was to identify biochemical endpoints of oestrogen action in the male rat during foetal and neonatal development, which may have potential for monitoring the level of "oestrogen" exposure of individual animals, either in infancy or […]

Read more

A3.1: Establishment and Management of a Research Inventory on the Indoor Environment (IERIE)

Substantial research has been underway for many years on the health effects of pollutants in domestic and commercial buildings. This project has developed a searchable database (termed IERIE) of recent, current and planned indoor environment research activities across Europe. Existing […]

Read more

B3.1-CUSS: Strategies for Success? Managing Chemical Risks in Small Workplaces: a Review of European Practice

The research project is essentially a review of literature and informed interest on the main factors that determine effective and sustainable risk management in the use of chemical substances in small enterprises and an exploration of the supports for their […]

Read more

EMSG19: Chemicals and Pregnancy Study-UK (CHAPS-UK): Multicentre Study of Occupational Exposure to Chemicals and Male Fertility

The research institutes will study 6000 men attending any of the 10 fertility clinics in the UK over a period of 2 years. They will be classified as either fertile or infertile on the basis of sperm parameters. Standardised methods […]

Read more

Cefic-Lri Programme Responsible Care

© Copyright 2017 Cefic | European Chemical Industry Council. All rights reserved | Terms and Conditions of Use