Cefic-lri Programme | European Chemical Industry Council

Projects

C1.5: European Sourcebook of Information Describing Human Exposures to Chemicals in the Environment (ExpoFacts)

European exposure factor data have been collected in one centrally available, freely accessible site on the Internet: the ExpoFacts database. The process of compiling the database required locating the exposure factor data and evaluating its general applicability and public availability. […]

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B3.1-CUSS: Strategies for Success? Managing Chemical Risks in Small Workplaces: a Review of European Practice

The research project is essentially a review of literature and informed interest on the main factors that determine effective and sustainable risk management in the use of chemical substances in small enterprises and an exploration of the supports for their […]

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EMSG12: Exposure to Endocrine-Disruptor Chemicals Assessed by Ligand-Receptor Interaction Analysis of Human Body Fluids

The objective of the research was to determine whether the levels of binding between oestrogenic chemicals and pure oestrogen receptor could be quantified in vitro using ligand receptor interaction analysis. The hope was that such technology might be usefully applied […]

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CC1-FOAR: Development of Criteria for Threshold Genotoxins: Interactions of Chemical Carcinogens With Cytoskeletal Macromolecules

This project will examine the ways in which chemicals that cause cancer and genetic damage interact with structural elements in human cells known as cytoskeletal proteins. Because proteins play a key role in cell division, interfering with their functioning can […]

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D1.1-SYNG: Study of the Role and Application of Biomarkers in the Management of the Health Risks Associated with Occupational Exposures to Chemicals

The objective of this project was to provide a concise and impartial view of the major developments in academic, institutional and industrial laboratories in Europe, USA and elsewhere working on biomarkers for monitoring human exposure to chemicals. The research into […]

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ECO3A-TUHH: MarSens – How Should We Deal with the Uncertainty in the Extrapolation of the Sensitivity of Marine Organisms to Narcotics? Critical Review of the State of the Art of Marine Risk Assessment and Recommendations for Future Research

The risk assessment of substances to the marine environment is linked with uncertainty due to several reasons, e.g. the marine environment encompasses a higher biodiversity than the freshwater environment. Moreover, the number of toxicity data on marine organisms for the […]

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EMSG16: Epidemiological Studies of Endocrine Disruptors and Human Health

Hypospadias is a male birth defect in which the urethral orifice is abnormally located on the ventral side of the penis. In western countries, the prevalence of hypospadias varies from 2 to 8 cases per 1000 live births. An increase […]

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CC1-UNEW/ZENE: Molecular Toxicology and Structure Activity Relationships in the Rodent Carcinogenesis of Industrially Important Dienes and the Relevance for Human Cancer

About one-half of chemicals tested for long-term health effects in laboratory rats and mice have been found to cause cancer. The accuracy of these tests in predicting human cancer risks needs to be fully understood, particularly for chemicals produced and […]

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D2.1-MRCI: Background Incidence of Key Biomarkers of Chemical Exposure within the General Population

The science of biomarkers and measurement of exposures via biomarkers has progressed substantially in the past ten years, resulting in several occupational exposure limits being set on the basis of biomarker measurement, and the acceptance of biomarkers as measurement of […]

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EMSG21: Endocrine Disruption in the Marine Environment (EDMAR)

The EDMAR programme is investigating whether there is evidence of changes in the reproductive health of marine life and if so, seeks to identify possible causes and potential impacts. Areas for research include: development of methods for the detection of […]

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