Cefic-lri Programme | European Chemical Industry Council

Complex environments

EMSG21: Endocrine Disruption in the Marine Environment (EDMAR)

The EDMAR programme is investigating whether there is evidence of changes in the reproductive health of marine life and if so, seeks to identify possible causes and potential impacts. Areas for research include: development of methods for the detection of […]

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EMSG25: Comparative Developmental and Reproductive Toxicity of Endocrine Disrupting Chemicals in Vivo Rat Model

The study will investigate sex steroid-regulated gene expression in two sexually dimorphic brain regions i.e. the preoptic region, the bed nucleus of stria terminalis and the ventromedial hypothalamic nucleus, which are part of the neural network controlling sexually dimorphic behaviours […]

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C1.5: European Sourcebook of Information Describing Human Exposures to Chemicals in the Environment (ExpoFacts)

European exposure factor data have been collected in one centrally available, freely accessible site on the Internet: the ExpoFacts database. The process of compiling the database required locating the exposure factor data and evaluating its general applicability and public availability. […]

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EMSG22: Endocrine Disruption in the Aquatic Environment; Laboratory Investigation of Endocrine-Active Chemicals

Laboratory studies are being conducted in which fish are exposed to defined concentrations of known chemicals. Natural steroids, synthetic steroids and xenoestrogens will be assessed. The choice of test chemicals will depend on field studies in the UK and Germany, […]

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RTD-INSERM: Neuroendocrine Effects of Endocrine Active Chemicals (EAC): a Literature Review

The mammalian brain and pituitary gland (hypophysis) are clearly target organs for steroid and thyroid hormone action. There is also evidence that prenatal (in utero) or neonatal (young) exposure to high concentrations of some chemicals can affect the developing nervous […]

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D1.1-SYNG: Study of the Role and Application of Biomarkers in the Management of the Health Risks Associated with Occupational Exposures to Chemicals

The objective of this project was to provide a concise and impartial view of the major developments in academic, institutional and industrial laboratories in Europe, USA and elsewhere working on biomarkers for monitoring human exposure to chemicals. The research into […]

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EMSG23: Endocrine Modulating Effects in Fish Along the Elbe River and in Reference Areas. Assessment of Risks Related to the Habitat Conditions and the Natural Variability of Endocrine Functions

The aim of the study is to identify effects caused by endocrine modulation in fish and evaluate these with respect to dysfunction in sex differentiation, development of functional organs as well as fecundity. Another aspect is the determination of the […]

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EMSG24: Environmental Oestrogens and the Neuro-Endocrine Regulation of Reproduction of Fish

The aim of the study was to study neuro-endocrine regulation, particularly the brain-pituitary-gonad (BPG) axis, 3 freshwater fish species (catfish, trout and tilapia) exposed to 4-nonyl phenol (4-NP) or oestradiol (EE). The research also sought to establish an immortalised gonadotroph […]

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D2.1-MRCI: Background Incidence of Key Biomarkers of Chemical Exposure within the General Population

The science of biomarkers and measurement of exposures via biomarkers has progressed substantially in the past ten years, resulting in several occupational exposure limits being set on the basis of biomarker measurement, and the acceptance of biomarkers as measurement of […]

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EMSG27: Environmental Effects on Uterine Tissues of Baltic Seals With Special Emphasis on Organochlorines and Uterine Leiomyomas

The study investigated whether leiomyomas in grey seals, collected during the period of decreased levels of organo-chlorines, were in a regressive phase; and whether the period of increased levels of organo-chlorines caused the leiomyomas to proliferate. In addition, in vitro […]

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