Cefic-lri Programme | European Chemical Industry Council

Projects

IA4.6: A Rat IGE Test for the Identification of Chemical Respiratory Allergens

Some chemicals can induce allergies, including allergy of the lungs and other parts of the respiratory tract. (Examples include acid anhydrides, certain diisocyanates, some platinum salts, certain reactive dyes and plicatic acid). This is an important occupational health problem because […]

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EMSG27: Environmental Effects on Uterine Tissues of Baltic Seals With Special Emphasis on Organochlorines and Uterine Leiomyomas

The study investigated whether leiomyomas in grey seals, collected during the period of decreased levels of organo-chlorines, were in a regressive phase; and whether the period of increased levels of organo-chlorines caused the leiomyomas to proliferate. In addition, in vitro […]

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EMSG25: Comparative Developmental and Reproductive Toxicity of Endocrine Disrupting Chemicals in Vivo Rat Model

The study will investigate sex steroid-regulated gene expression in two sexually dimorphic brain regions i.e. the preoptic region, the bed nucleus of stria terminalis and the ventromedial hypothalamic nucleus, which are part of the neural network controlling sexually dimorphic behaviours […]

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CC2-UNBI: Determination of Human and Rodent Gene Expression Patterns in Response to Chemical Carcinogens: Facilitation of Knowledge-Based Human Risk Assessment From Molecular Mechanisms

Naturally-occurring and man-made chemicals are widespread in the environment. Predictions of human health risks are usually based on laboratory tests on animals such as rats and mice. Occasionally, cancer does occur in mice alone or in both rats and mice […]

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R2-TNO: The Role of Irritancy and Irritant-Induced Inflammation in the Elicitation of Respiratory Hypersensitivity Reactions

A range of low molecular weight chemicals can cause adverse reactions in the airways such as allergic asthma, including occupational asthma. Allergies involve a generally symptom-free induction phase where sensitisation is induced, and an elicitation (challenge) phase, where inhalation of […]

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EMSG28: Development, Validation and Application of in Vitro and in Vivo Test Systems for Non-Oestrogenic Endocrine Disrupting Chemicals in Wildlife

The project will provide information on effective in vitro (T-screen & Keratonisation Assay) and in vivo assays (metamorphosis, migration and prolonged FETAX-assay) for alterations of thyroid and retinoid dependent processes. It will bridge the gap between the in vitro and […]

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