Cefic-lri Programme | European Chemical Industry Council

Projects

A3.3: The EXPOLIS-Index Study, Human Exposure Patterns for Health Risk Assessment:Indoor Determinants of Personal Exposures in the European Expolis Population in Athens, Basel, Grenoble, Milan, Helsinki, Oxford And Praha

Exposure assessment plays a key role in the risk assessment procedure. In order to quantify the associated risk and health impact of a possible pollutant, it is necessary to obtain a description of the full-range of exposure distribution. This project […]

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ECO3A-TUHH: MarSens – How Should We Deal with the Uncertainty in the Extrapolation of the Sensitivity of Marine Organisms to Narcotics? Critical Review of the State of the Art of Marine Risk Assessment and Recommendations for Future Research

The risk assessment of substances to the marine environment is linked with uncertainty due to several reasons, e.g. the marine environment encompasses a higher biodiversity than the freshwater environment. Moreover, the number of toxicity data on marine organisms for the […]

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EMSG20: Environmental Factors and Male Reproductive Functions. A Cohort Study of the Incidence of Cryptorchidism and Hypospadia in 5000 Newborn Boys in the Rotterdam Area

This is a study of 10,000 men, their (pregnant) partners and their new-born children. Information will be collected on the incidence of urogenital disorders such as Cryptorchidism, Hypospadia, lifestyle, working conditions of the male partner and time to pregnancy. The […]

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C1.3: Establish a Database of a Number of Parameters Sufficient Relevant for Reliable Prediction of European Consumer Exposures

Many chemicals are used daily in the home, in diverse end-uses such as cleaning, renovating and caring for houseplants. Product labels give advice on safe use, but there is scope to improve understanding of potential risks. One approach is to […]

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EMSG21: Endocrine Disruption in the Marine Environment (EDMAR)

The EDMAR programme is investigating whether there is evidence of changes in the reproductive health of marine life and if so, seeks to identify possible causes and potential impacts. Areas for research include: development of methods for the detection of […]

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EMSG25: Comparative Developmental and Reproductive Toxicity of Endocrine Disrupting Chemicals in Vivo Rat Model

The study will investigate sex steroid-regulated gene expression in two sexually dimorphic brain regions i.e. the preoptic region, the bed nucleus of stria terminalis and the ventromedial hypothalamic nucleus, which are part of the neural network controlling sexually dimorphic behaviours […]

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C1.5: European Sourcebook of Information Describing Human Exposures to Chemicals in the Environment (ExpoFacts)

European exposure factor data have been collected in one centrally available, freely accessible site on the Internet: the ExpoFacts database. The process of compiling the database required locating the exposure factor data and evaluating its general applicability and public availability. […]

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EMSG22: Endocrine Disruption in the Aquatic Environment; Laboratory Investigation of Endocrine-Active Chemicals

Laboratory studies are being conducted in which fish are exposed to defined concentrations of known chemicals. Natural steroids, synthetic steroids and xenoestrogens will be assessed. The choice of test chemicals will depend on field studies in the UK and Germany, […]

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RTD-INSERM: Neuroendocrine Effects of Endocrine Active Chemicals (EAC): a Literature Review

The mammalian brain and pituitary gland (hypophysis) are clearly target organs for steroid and thyroid hormone action. There is also evidence that prenatal (in utero) or neonatal (young) exposure to high concentrations of some chemicals can affect the developing nervous […]

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