C9: Mining the developmental toxicity genome in the zebrafish embryo test to develop a spatio-temporal map on morphogenesis and associated biomarker.
The LRI C9 project “zet-o-map” aims to develop better tools for the identification of teratogenic compounds. One of the most promising assays is the zebrafish embryo teratogenicity assay (ZETA).
B23 – Optimizing the benefit of REACH worker exposure assessments: ensuring meaningful health risk communication
The main objective of the project is to provide a substantial contribution to optimisation of information on (safe) use conditions, specifically in REACH.
EMSG60 – Incidence trends of selected endocrine-related diseases and conditions in Europe and North America, and the contribution of changes in human reproduction
The first aim of the project is to investigate whether there has been an increase over time in the incidence of 14 diseases and conditions that may be associated with exposure to endocrine active substances.
B19.2 – Refinement of a framework for extrapolating of worker exposure measurement data
LRI B19.2 is an extension of Cefic-LRI B19 project: 'Extrapolating the Applicability of Worker Exposure Measurement Data'. The objective is to improve on the framework delivered in the previous B19 project, by 1) re-assessing the existing case studies in light […]
B15.3 – ECEL v3.0: Technical improvements and population of the integrated risk management measure (RMM) library
B15.3 is an extension of the “Cefic-LRI B15-2 project: Development of an integrated risk management measure library”. The main goal of this proposal is to upgrade ECEL v2.0 to ECEL v3.0 such that it is a well-designed, user-friendly tool with […]
B12.3 – Assessing the relevance of the dust contribution in consumer exposure to substances from consumer products and articles (DustEx extension)
Human exposure to semi-volatile organic compounds (SVOCs) present in materials is of great interest because of the large number of SVOCs used for different purposes in different materials; ranging from plasticizers in PVC to flame retardants in upholstery and clothing […]
B21 – In Vitro Data to Parameterise PBPK Models For Inhalation Exposure
This project aims at the generation and application of physiologically derived transport parameters in a PBPK model focusing on a more detailed description of substance uptake through the respiratory tract/via the inhalational route. This PBPK model is aimed to be […]
C7 – ELUMICA – Elucidating Microbial Metabolic Capacity
This project will carry out collaborative, mechanistically oriented research centered around the following three aims: Identify and quantify alterations in endogenous and xenobiotic-derived microbial metabolites; provide a basis to examine interspecies and interindividual differences in intestinal microbial metabolism; and develop […]
EMSG59 – Developing a quantitative AOP for liver-mediated thyroid modulation after prenatal exposure to a xenobiotic compound in the rat
This project aims at understanding the consequences of chemical-induced changes in liver physiology on thyroid hormone balance and related adverse health effects. The project will focus on prenatal exposure and development of the foetus and new-born in the rat as […]
ECO46 – Improved aquatic Testing and Assessment of cationic Polymers (iTAP)
The aim of this PROJECT PROPOSAL is to collate and update the existing global knowledge base on the available methods for the assessment of cationic polymers toxicity, fate properties as well as regarding their known descriptors used to develop Structure […]