Cefic-lri Programme | European Chemical Industry Council

Projects

ECO35: Interference of hepatotoxicity with endocrine activity in fish

The project proposed is driven by the hypothesis that hepatotoxicity may positively or negatively interfere with vitellogenin production, which is used as a key marker of endocrine activity in current OECD test guidelines 229, 230 and 234 and the proposed […]

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ECO34: A tiered testing strategy for rapid estimation of bioaccumulation by a combined modelling – in vitro testing approach

The overall objective of our research is to reduce the uncertainty related to the estimation of bioaccumulation of organic chemicals in fish in ecological risk assessment (ERA). Based on a combination of different in vitro approaches to estimate chemical uptake […]

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ECO32: Environmental risk assessment of poorly soluble substances: Improved tools for assessing biodegradation, (de)sorption, and modeling

This project proposal will answer the following questions: Objective: How can the aqueous phase biodegradation kinetics of poorly water soluble substances be measured without the influence of bioavailability factors, i.e., without (de)sorption effects? Objective: How can the desorption rates of […]

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ECO31: Identifying strategies that will provide greater confidence in estimating the degradation rates of organic chemicals in water, soil and sediment

In the work described in this proposal, the project team aims to identify strategies that will provide greater confidence in estimating the degradation rates of organic chemicals in the environment. There are two main hypotheses that will be investigated: Multivariate […]

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AIMT6-VITO: CON4EI: CONsortium for in vitro Eye Irritation testing strategy

Measurement of ocular irritancy is a necessary step in the safety evaluation of both industrial and consumer products. Assessment of the acute eye irritation potential is therefore part of the international regulatory requirements for testing of chemicals. This project will: […]

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B14-RIFM: Skin Sensitisation – Chemical Applicability Domain of the Local Lymph Node Assay (LLNA)

Since the publication of the OECD AOP for skin sensitisation in 2012, there have been even greater efforts to anchor the development and evaluation of new in vitro and in chemico assays to key events within the AOP. Much of […]

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ECO11-UNEW: Towards rationally designed hazard, risk and persistency assessment: Putting the “bio” back into biodegradability tests

The objectives of this project are as follows: Objective 1a.  Determine the extent and variation in microbial diversity of environmental sources used in biodegradation studies i.e. activated sludge, fresh-, estuarine- and marine-waters. Objective 1b.  Examine the relationship between microbial diversity, […]

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ECO26-RAD: Adapt SimpleTreat for simulating behavior of chemical substances during industrial sewage treatment

REACH Guidance for Chemical Safety Assessment makes use of mathematical simulation of the retention of chemical substances during waste water treatment. REACH R-16 describes the use of the model SimpleTreat, developed by Struijs and co-workers at RIVM, which simulates the […]

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ECO22-IRAS: Advancing the use of passive sampling in risk assessment and management of contaminated sediments: an inter-laboratory comparison study on measurements of freely dissolved (bioavailable) concentrations using different passive sampling formats

The main objective of this study is to map the state of the art in passive sampling sediments and to investigate which measures we can take to reduce any inter-method and -laboratory variation, in order to increase confidence in the […]

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EEM9.3-IC: Linking LRI AMBIT Chemoinformatic system with the IUCLID Substance database to Support Read-across of Substance endpoint data and Category formation

A major hurdle in using chemoinformatic systems is the lack of easily accessible data on substance identity including structures and composition e.g. constituents, impurities and additives as well as high quality, detailed endpoint data of chemical substances. This project is […]

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