Cefic-lri Programme | European Chemical Industry Council

Projects

ECO43: Improving sediment toxicity testing design and data interpretation for very hydrophobic substances

The general objective of the proposed research is to improve sediment toxicity testing design, performance, and data interpretation for VHOCs and to develop guidance in order to maximize realism and value of future testing and thereby to support product and […]

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ECO41: Enhanced Screening Methods to Determine Bioaccumulation Potential of Chemicals in Air-Breathing Species

This project plans to develop an approach for assessing bioaccumulation of neutral hydrophobic organic chemicals in air-breathing species based on physical chemical properties (i.e. KOW and KOA) and in-vitro biotransformation bioassay data using mammalian liver S9 in vitro bioassays.

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ECO35: Interference of hepatotoxicity with endocrine activity in fish

The project proposed is driven by the hypothesis that hepatotoxicity may positively or negatively interfere with vitellogenin production, which is used as a key marker of endocrine activity in current OECD test guidelines 229, 230 and 234 and the proposed […]

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ECO34: A tiered testing strategy for rapid estimation of bioaccumulation by a combined modelling – in vitro testing approach

The overall objective of our research is to reduce the uncertainty related to the estimation of bioaccumulation of organic chemicals in fish in ecological risk assessment (ERA). Based on a combination of different in vitro approaches to estimate chemical uptake […]

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ECO32: Environmental risk assessment of poorly soluble substances: Improved tools for assessing biodegradation, (de)sorption, and modeling

This project proposal will answer the following questions: Objective: How can the aqueous phase biodegradation kinetics of poorly water soluble substances be measured without the influence of bioavailability factors, i.e., without (de)sorption effects? Objective: How can the desorption rates of […]

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ECO31: Identifying strategies that will provide greater confidence in estimating the degradation rates of organic chemicals in water, soil and sediment

In the first phase of this project (ECO31.1), the team aimed to identify strategies that will provide greater confidence in estimating the degradation rate constants of organic chemicals in the environment. To meet this objective, the team performed an extensive […]

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AIMT6-VITO: CON4EI: CONsortium for in vitro Eye Irritation testing strategy

Measurement of ocular irritancy is a necessary step in the safety evaluation of both industrial and consumer products. Assessment of the acute eye irritation potential is therefore part of the international regulatory requirements for testing of chemicals. This project will: […]

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B14-RIFM: Skin Sensitisation – Chemical Applicability Domain of the Local Lymph Node Assay (LLNA)

Since the publication of the OECD AOP for skin sensitisation in 2012, there have been even greater efforts to anchor the development and evaluation of new in vitro and in chemico assays to key events within the AOP. Much of […]

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ECO11-UNEW: Towards rationally designed hazard, risk and persistency assessment: Putting the “bio” back into biodegradability tests

The objectives of this project are as follows: Objective 1a.  Determine the extent and variation in microbial diversity of environmental sources used in biodegradation studies i.e. activated sludge, fresh-, estuarine- and marine-waters. Objective 1b.  Examine the relationship between microbial diversity, […]

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ECO26-RAD: Adapt SimpleTreat for simulating behavior of chemical substances during industrial sewage treatment

REACH Guidance for Chemical Safety Assessment makes use of mathematical simulation of the retention of chemical substances during waste water treatment. REACH R-16 describes the use of the model SimpleTreat, developed by Struijs and co-workers at RIVM, which simulates the […]

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