Cefic-lri Programme | European Chemical Industry Council

Intelligent testing

EMSG42: Increase of the robustness of the fish endocrine assay and avoidance of irrelevant endpoints

The objective of this study was to determine the influence of the test items potassium permanganate, 2-methoxyethanol and octanol to reproduction and the endocrine system of fathead minnow (Pimephales promelas). For this purpose, mature male and female fathead minnow were exposed in […]

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21DAY: Phase 3 of the validation of the OECD Fish Screening Assay

The eight studies in the attached report were conducted as part of OECD Test Guideline program to validate a standardized OECD protocol for a 21-day fish screening assay for the detection of endocrine active substances (i.e. estrogen, aromatase inhibitors, androgen). […]

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D2.2-VITO: Generation and Application of a Model to Determine Intra- and Inter-individual Variation in Biomarkers

Biomarkers which reflect levels of pollutants in the human body offer a unique opportunity to investigate impact of environmental pollution on humans. Biomarker levels in the general population are influenced by genetic, physiological and external factors. Knowledge on which factors […]

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B2.3-IOM: Variability and Uncertainty in Chemical Exposures for Regulatory Risk Assessment

The aim of this project is to investigate how the variability and uncertainty of occupational inhalation exposure information may be better incorporated into the European regulatory risk assessment process. In this proposal, we have chosen to focus specifically on inhalation […]

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EEM4: Development of Tools for Probabilistic Uncertainty Analysis in Environmental Risk Assessment of Chemicals

The risk to wildlife or the environment posed by a given chemical depends on whether its environmental concentration is greater than set quality objectives (the risk quotient). Both environmental concentrations and quality objectives are calculated based on chance (probability), a […]

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B3.7-HSL: The Rapid Generation And Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model)

The widespread use and acceptance of PBPK modelling has been advocated for many years, as this technique offers a more scientific and quantitative approach to chemical risk assessment, as well as offering the opportunity of a marked reduction in the […]

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EMSG7: Screening Test in Fish – Aquatic Toxicity Project A

An in vivo screening test for oestrogenicity was developed jointly by three laboratories by measuring vitellogenin in fathead minnows after up to 21 days exposure. This method will be further refined by determination of (anti-)androgens and aromatase inhibitors in the […]

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A1.2-UNAB: Database Of European Workplace Exposure Research Activities (HEROX)

Cefic identified a need for an inventory of European research on human workplace exposure to chemicals. Access to this information is needed for setting safe occupational exposure limits and to help quantify economic and health implications of exposures. A database […]

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EMSG34A: Validation of the OECD protocol for the surgical castrate rat (Hershberger) assay

The objective of this project was the evaluation and validation of the Hershberger assay as part of the official OECD validation of this test method. This test, developed under the EDTA programme, is designed to help detect chemicals interfering with […]

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A1.3-UNAB: Development Of A Database For Workplace Exposure Measurements

Measurement of human exposure at work forms the cornerstone of risk management strategies. With the advent of powerful computer databases these measurements have been collected in several parts of Europe, by industry, government agencies and others such as universities and […]

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