Cefic-lri Programme | European Chemical Industry Council

Intelligent testing

EMSG42: Increase of the robustness of the fish endocrine assay and avoidance of irrelevant endpoints

The objective of this study was to determine the influence of the test items potassium permanganate, 2-methoxyethanol and octanol to reproduction and the endocrine system of fathead minnow (Pimephales promelas). For this purpose, mature male and female fathead minnow were exposed in […]

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21DAY: Phase 3 of the validation of the OECD Fish Screening Assay

The eight studies in the attached report were conducted as part of OECD Test Guideline program to validate a standardized OECD protocol for a 21-day fish screening assay for the detection of endocrine active substances (i.e. estrogen, aromatase inhibitors, androgen). […]

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D2.2-VITO: Generation and Application of a Model to Determine Intra- and Inter-individual Variation in Biomarkers

Biomarkers which reflect levels of pollutants in the human body offer a unique opportunity to investigate impact of environmental pollution on humans. Biomarker levels in the general population are influenced by genetic, physiological and external factors. Knowledge on which factors […]

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A1.3-UNAB: Development Of A Database For Workplace Exposure Measurements

Measurement of human exposure at work forms the cornerstone of risk management strategies. With the advent of powerful computer databases these measurements have been collected in several parts of Europe, by industry, government agencies and others such as universities and […]

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EMSG34B: Validation of the OECD Protocol for the Rat Uterotrophic assay

The objective of this project was the evaluation and validation of the uterotrophic assay as part of the official OECD validation of this test method. This uterotrophic bioassay is intended to identify the in vivo activity of compounds that are […]

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D1.1-NOFE: Biomarkers of Exposure Trends and Key Developments

The aim of the study is to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study will […]

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EMSG33: Chemical Repository

OECD Test Guideline Validation: to provide a set of defined test chemicals for the OECD test methods development for endocrine active chemicals and to guarantee that test method validation under OECD leads to reliable results by always using the same […]

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A2.5-TNO: Evaluation of Real and Theoretical Effectiveness of Skin Protection Equipment

The aim of the project was to analyse the parameters of dermal exposure and protection which are most relevant for human health; the quality of data from today's practice of exposure monitoring and PPE testing; the existing knowledge and gaps […]

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A1.3-IOM: Establish the Framework and Operating system for a Cefic Database (CEMAS)

The CEMAS (Cefic Exposure MAnagement System) research project has led to the development of a workplace chemicals exposure and risk evaluation tool that facilitates the delivery of solutions specific to sector groups, including targeted advice from sectors on assessing and […]

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ECO4-RIVO: MonitoringBase. Collation and Evaluation of Monitoring Programmes and Measured Environmental Concentration Data on Organic Chemicals in European Aquatic Environments

To facilitate retrieval of background concentrations and ranges of organic chemical concentrations in the marine and freshwater environment as input for various LRI models (e.g. multi-media, estuary models), ”MonitoringBase” was developed. This database includes information, references and links to more […]

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