Cefic-lri Programme | European Chemical Industry Council

Intelligent testing

B3.7-HSL: The Rapid Generation And Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model)

The widespread use and acceptance of PBPK modelling has been advocated for many years, as this technique offers a more scientific and quantitative approach to chemical risk assessment, as well as offering the opportunity of a marked reduction in the […]

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EMSG7: Screening Test in Fish – Aquatic Toxicity Project A

An in vivo screening test for oestrogenicity was developed jointly by three laboratories by measuring vitellogenin in fathead minnows after up to 21 days exposure. This method will be further refined by determination of (anti-)androgens and aromatase inhibitors in the […]

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A1.2-UNAB: Database Of European Workplace Exposure Research Activities (HEROX)

Cefic identified a need for an inventory of European research on human workplace exposure to chemicals. Access to this information is needed for setting safe occupational exposure limits and to help quantify economic and health implications of exposures. A database […]

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EMSG34A: Validation of the OECD protocol for the surgical castrate rat (Hershberger) assay

The objective of this project was the evaluation and validation of the Hershberger assay as part of the official OECD validation of this test method. This test, developed under the EDTA programme, is designed to help detect chemicals interfering with […]

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A1.3-UNAB: Development Of A Database For Workplace Exposure Measurements

Measurement of human exposure at work forms the cornerstone of risk management strategies. With the advent of powerful computer databases these measurements have been collected in several parts of Europe, by industry, government agencies and others such as universities and […]

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EMSG34B: Validation of the OECD Protocol for the Rat Uterotrophic assay

The objective of this project was the evaluation and validation of the uterotrophic assay as part of the official OECD validation of this test method. This uterotrophic bioassay is intended to identify the in vivo activity of compounds that are […]

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D1.1-NOFE: Biomarkers of Exposure Trends and Key Developments

The aim of the study is to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study will […]

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EMSG33: Chemical Repository

OECD Test Guideline Validation: to provide a set of defined test chemicals for the OECD test methods development for endocrine active chemicals and to guarantee that test method validation under OECD leads to reliable results by always using the same […]

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A2.5-TNO: Evaluation of Real and Theoretical Effectiveness of Skin Protection Equipment

The aim of the project was to analyse the parameters of dermal exposure and protection which are most relevant for human health; the quality of data from today's practice of exposure monitoring and PPE testing; the existing knowledge and gaps […]

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A1.3-IOM: Establish the Framework and Operating system for a Cefic Database (CEMAS)

The CEMAS (Cefic Exposure MAnagement System) research project has led to the development of a workplace chemicals exposure and risk evaluation tool that facilitates the delivery of solutions specific to sector groups, including targeted advice from sectors on assessing and […]

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