Cefic-lri Programme | European Chemical Industry Council

Intelligent testing

EEM4: Development of Tools for Probabilistic Uncertainty Analysis in Environmental Risk Assessment of Chemicals

The risk to wildlife or the environment posed by a given chemical depends on whether its environmental concentration is greater than set quality objectives (the risk quotient). Both environmental concentrations and quality objectives are calculated based on chance (probability), a […]

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D1.1-NOFE: Biomarkers of Exposure Trends and Key Developments

The aim of the study is to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study will […]

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EMSG7: Screening Test in Fish – Aquatic Toxicity Project A

An in vivo screening test for oestrogenicity was developed jointly by three laboratories by measuring vitellogenin in fathead minnows after up to 21 days exposure. This method will be further refined by determination of (anti-)androgens and aromatase inhibitors in the […]

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A2.5-TNO: Evaluation of Real and Theoretical Effectiveness of Skin Protection Equipment

The aim of the project was to analyse the parameters of dermal exposure and protection which are most relevant for human health; the quality of data from today's practice of exposure monitoring and PPE testing; the existing knowledge and gaps […]

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EMSG34A: Validation of the OECD protocol for the surgical castrate rat (Hershberger) assay

The objective of this project was the evaluation and validation of the Hershberger assay as part of the official OECD validation of this test method. This test, developed under the EDTA programme, is designed to help detect chemicals interfering with […]

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A1.3-IOM: Establish the Framework and Operating system for a Cefic Database (CEMAS)

The CEMAS (Cefic Exposure MAnagement System) research project has led to the development of a workplace chemicals exposure and risk evaluation tool that facilitates the delivery of solutions specific to sector groups, including targeted advice from sectors on assessing and […]

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EMSG34B: Validation of the OECD Protocol for the Rat Uterotrophic assay

The objective of this project was the evaluation and validation of the uterotrophic assay as part of the official OECD validation of this test method. This uterotrophic bioassay is intended to identify the in vivo activity of compounds that are […]

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CC2-MRCT: Gene Expression Profiling of Skin Carcinogenesis in Mice Using cDNA Microarrays

Skin cancers are very common in humans - with around one million cases/year in the US - and their development can be affected by stimulators of growth such as certain chemicals. Although initiation is clearly extremely important, clonal expansion (promotion) […]

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