Cefic-lri Programme | European Chemical Industry Council

Projects

B1.1-FRAU: Identification of Structure Activity Relationships Alerts for Substances With Low NOELs (REPDOSE)

The toxicological data profiles of many of the more than 100,000 substances included in the EINECS are incomplete. Scientific tools are needed to minimize test requirements and to prioritise research needs. Here consideration of Structure Activity Relationships (SAR) could be […]

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ECO2A-ASTRA: Understanding and Measurement of Persistence in the Marine and Terrestrial Compartments

The persistence of a chemical in the environment - how resistant it is to being broken down in nature - is hard to predict. Its tendency to build up in living organisms - to bioconcentrate or bioaccumulate - is similarly […]

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B2.1-TNO: Characterisation of Uncertainty and Variation in Assessment of Chronic Occupational Exposure

Many adverse health effects of chemical exposure occur after repeated contact over long periods. In assessing the risks of such chronic effects in the workplace, "reasonable worst case" estimates of exposure during a shift or working day are often used. […]

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MISTRA: A New Strategy for the Risk Management of Chemicals: MISTRA and Persistence

To evaluate the persistency of the selected model compounds in the environmental matrices air, water, soil and sediment. Reaction mechanisms and degradation pathways of the model compounds are studied. A theoretical approach will be made to arrive at the conceptual […]

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B2.2-FoBiG: Provide Examples Where Risk Characterisations can be Conducted With the Existing and Possible Inadequate Data Sets

This project will evaluate the estimates used today by several organisations (e.g. U.S.-EPA, WHO, EU) to assess the human health risks of chemical exposure, which result in the derivation of human limit values such as acceptable daily intake, reference doses […]

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EEM1-ASTRA: Identification and Evaluation of Emission Databases in Europe

Estimating how much of a particular chemical is released to the environment is key to assessing likely levels of exposure and risk to humans and the environment. Such estimates are often based on very general information due to a lack […]

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B2.3-IOM: Variability and Uncertainty in Chemical Exposures for Regulatory Risk Assessment

The aim of this project is to investigate how the variability and uncertainty of occupational inhalation exposure information may be better incorporated into the European regulatory risk assessment process. In this proposal, we have chosen to focus specifically on inhalation […]

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EEM4: Development of Tools for Probabilistic Uncertainty Analysis in Environmental Risk Assessment of Chemicals

The risk to wildlife or the environment posed by a given chemical depends on whether its environmental concentration is greater than set quality objectives (the risk quotient). Both environmental concentrations and quality objectives are calculated based on chance (probability), a […]

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B3.7-HSL: The Rapid Generation And Analysis of Physiologically-Based Pharmacokinetic Models (PBPK Model)

The widespread use and acceptance of PBPK modelling has been advocated for many years, as this technique offers a more scientific and quantitative approach to chemical risk assessment, as well as offering the opportunity of a marked reduction in the […]

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EMSG7: Screening Test in Fish – Aquatic Toxicity Project A

An in vivo screening test for oestrogenicity was developed jointly by three laboratories by measuring vitellogenin in fathead minnows after up to 21 days exposure. This method will be further refined by determination of (anti-)androgens and aromatase inhibitors in the […]

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