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AIMT1-PG: Evaluation of Signal Transduction Pathways in Model Organisms as Critical Mediators of Developmental Toxicity

Principal Investigator

Dr. George Daston
Miami Valley Laboratories
Procter & Gamble
11810 E. Miami River Rd.
P.O. Box 538707
Cincinnati, OH 45253 USA
Tel: +1 513 627 2886

Collaborators

Dr. Jorge Naciff, Procter & Gamble, USA
Mr. Gary Overmann, Procter & Gamble, USA

Description

The overall objective of the project is to determine whether model organisms with genetically sensitized signal transduction pathways can be used as predictors of mammalian developmental toxicity.

Specific objectives:

– Evaluate the effect of model developmental toxicants on the morphological development of a limited number of strains of Drosophila, C. elegans, and zebrafish that are sensitized for specific signal transduction pathways.  Results using the sensitized strains will be compared either with wild-type organisms or with organisms heterozygous for the sensitizing mutations.

– Evaluate the effect of model developmental toxicants on the biochemical function of key signal transduction pathways to further support the biological relevance, at a molecular level, for the prediction of mammalian developmental toxicity.

– Determine whether human-relevant metabolizing systems can be incorporated into the sensitized screens.

Related Publications

Research project summary:

Evaluation of Signal Transduction Pathways in Model Organisms as Critical Mediators of Developmental Toxicity by G. Daston, J. Naciff, G. Overmann, Y. Shan, X. Wang, S. Patel and Jing Lu

Poster:

Signal Transduction Pathways: Potential Foundation for Developmental Toxicity Alternatives by George Daston

Timeline: June 2007 > December 2009

LRI funding: €200,400

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