Dr. Fitz Kalberlah
Forschungs- und Beratungsinstitut Gefahrstoffe (FoBiG) GmbH
D- 79098 Freiburg
Tel: +49 761 38608 11
Fax: +49 761 38608 20
LRI Monitor: Dr. Gauke Veenstra-Shell Chemicals Ltd.
This project will evaluate the estimates used today by several organisations (e.g. U.S.-EPA, WHO, EU) to assess the human health risks of chemical exposure, which result in the derivation of human limit values such as acceptable daily intake, reference doses or reference concentrations or margins of safety. It will document the ”state of the art” in substance-specific risk assessment and describe the influence of several factors on the uncertainty inherent in the final result. Further, the possibilities of probabilistic risk assessment methods to characterize and quantify uncertainty are addressed.some ways in which uncertainty can be handled (probabilistic approaches). This will help improve understanding of the actual increase in risk associated with exposures above ”safe” limits such as occupational exposure levels or maximum allowable soil concentrations. It will enable risk managers to take greater account of parameters which have a major influence on risk. (Health risks other than cancer will be considered.)
Kalberlah, F., Schneider, K., Schuhmacher-Wolz, U., 2003 Uncertainty in toxicological risk assessment for non-carcinogenic health effects Regulatory Toxicology and Pharmacology, Vol. 37, 2003, 92-104