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B2.2-FoBiG: Provide Examples Where Risk Characterisations can be Conducted With the Existing and Possible Inadequate Data Sets

Principal Investigator

Dr. Fitz Kalberlah
Forschungs- und Beratungsinstitut Gefahrstoffe (FoBiG) GmbH
Werderring 16
D- 79098 Freiburg
fritz.kalberlah@fobig.de
Tel: +49 761 38608 11
Fax: +49 761 38608 20

Collaborators

LRI Monitor: Dr. Gauke Veenstra-Shell Chemicals Ltd.
gauke.e.veenstra@opc.shell.com

Description

This project will evaluate the estimates used today by several organisations (e.g. U.S.-EPA, WHO, EU) to assess the human health risks of chemical exposure, which result in the derivation of human limit values such as acceptable daily intake, reference doses or reference concentrations or margins of safety. It will document the ”state of the art” in substance-specific risk assessment and describe the influence of several factors on the uncertainty inherent in the final result. Further, the possibilities of probabilistic risk assessment methods to characterize and quantify uncertainty are addressed.some ways in which uncertainty can be handled (probabilistic approaches). This will help improve understanding of the actual increase in risk associated with exposures above ”safe” limits such as occupational exposure levels or maximum allowable soil concentrations. It will enable risk managers to take greater account of parameters which have a major influence on risk. (Health risks other than cancer will be considered.)

Related Publications

Kalberlah, F., Schneider, K., Schuhmacher-Wolz, U., 2003 Uncertainty in toxicological risk assessment for non-carcinogenic health effects Regulatory Toxicology and Pharmacology, Vol. 37, 2003, 92-104

Timeline: January 2001 > May 2002

LRI funding: €37,275

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