Cefic-lri Programme | European Chemical Industry Council

ECO12: Validation Chemicals for Assessing Biodegradation Tests

Principal Investigator

Dr. Mike Comber
Mike Comber Consulting sprl
Square Prevost-Delaunay 123
B-1030, Bruxelles
Belgium 
Tel: +32 2 2416099
Fax: +32 2 2416099

Collaborators

Martin Holt, private consultant, UK
Mark Crane, WCA Environment, UK

Description

This project aims to develop a list of reference chemicals covering a range of environmental persistence and non-persistence. This reference set would be available for use to validate modifications to existing biodegradation test methods and to develop new test methods. The validation set would also help address concerns that some of the modifications or new methods could result in tests becoming too powerful or overly protective. The aim of the research is to establish such a list of chemicals, with an agreed (by regulators and industry) set of properties and characterized set of degradation behaviour. The reference set of chemicals would be relevant to projects addressing:

– Compartment persistence / biotransformation
– Bioavailability and bound residues
– Determination of test method variability, e.g. via ring testing
– Field monitoring/exposure model validation

As such, it is considered essential that the project has a good over-sight panel of regulators and Industry representatives who will aid the acceptability of the validation set for the purposes described.

Related Publications

Review on Refinement of biodegradation tests methodologies and the proposed utility of new microbial ecology techniques by Kowalczyk A., James M. T, Price O.R., Snape R.J., van Egmond R.A., Finnegan C.J,
Schäfer H., Davenport R.J., Bending G.D., Ecotoxicology and Environmental Safety 111 (2015) 9-22

Project Final Report: Developing a set of reference chemicals for use in biodegradability tests for assessing the persistency of chemicals

Timeline: December 2008 > December 2009

LRI funding: €75,000

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