Cefic-lri Programme | European Chemical Industry Council

ECO13: Development, application and evaluation of model-based screening procedures for PBT chemicals and POPs (SCREEN-POP)

Principal Investigator

Prof. Michael McLachlan
SE-106 91 Stockholm
Tel: +46 8 674 7228
Fax: +46 8 674 7637

Collaborators

Prof. Frank Wania, Dr. Jon Arnot – University of Toronto Scarborough, Canada
Dr. Knut Breivik – University of Oslo, Norway

Description

The scientific objectives of this project are:

1.To create a tiered screening system for identifying potential PBTs and POPs amongst existing chemicals;
2.To verify whether the potential PBTs / POPs identified in the screening program are present in the European background environment / the remote Arctic;
3.To evaluate the efficacy of the tiered screening system for identifying PBTs and POPs.

The broader objective of the project is to contribute to increased safety in the use of chemicals and to foster society’s acceptance of chemicals by providing a novel and effective tool to identify chemicals that could be deleterious to the environment or human health.

Related Publications

Michael S. McLachlan et al. (2014). Using Model-Based Screening to Help Discover Unknown Environmental Contaminants. Environmental Science & Technology. 2014, 48, 7264−7271.

Quinn C.L. and Wania F. (2012). Understanding Differences in the Body Burden-Age Relationships of Bioaccumulating Contaminants Based on Population Cross Sections versus Individuals. Environmental Health Perspectives. 120(4), 554-559.

Arnot J.A., Brown T.N., Wania F., Breivik K. and McLachlan M.S. (2012). Prioritizing Chemicals and Data Requirements for Screening-Level Exposure and Risk Assessment. Environmental Health Perspectives. 120(11), 1565-70.

Brown T.N., Arnot J.A. a,d Wania F. (2012). Iterative Fragment Selection: A Group Contribution Approach to Predicting Fish Biotransformation Half-Lives. Environmental Science & Technology. 46(15), 8253-8260.

Breivik K., Arnot J.A., Brown T.N., McLachlan M.S. and Wania F. (2012). Screening organic chemicals in commerce for emissions in the context of environmental and human exposure. Journal of Environmental Monitoring. 14, 2028-2037.

Gama S., Mackay D. and Arnot J.A. (2012). Selecting and designing chemicals: application of a mass balance model of chemical fate, exposure and effects in the environment. Green Chemistry. 14, 1094-1102.

Quinn C.L., Wania F., Czub G. and Breivik K. (2011). Investigating Intergenerational Differences in Human PCB Exposure due to Variable Emissions and Reproductive Behaviors. Environmental Health Perspectives. 119(5), 641-646.

Zhang X., Brown T.N., Wania F., Heimstad E.S. and Goss K-U. (2010). Assessment of chemical screening outcomes based on different partitioning property estimation methods. Environment International. 36(6), 514-520.

Presentations:

Bioaccumulation Assessment: Evolution or Revolution? by M.S. McLachlan, M. Adolfsson-Erici, G. í…kerman, A.Jahnke and M. MacLeod

Dynamic, linked fate and bioaccumulation models as tools in chemical management by M. McLachlan, F. Wania, K. Breivik and J. Arnot

Poster:

QSARs and mass balance models to screen organic chemicals for human exposure by Jon A. Arnot, Trevor N. Brown, Frank Wania, Knut Breivik and Michael S. McLachlan

 

Timeline: December 2008 > December 2011

LRI funding: €400,000

Cefic-Lri Programme Responsible Care

© Copyright 2017 Cefic | European Chemical Industry Council. All rights reserved | Terms and Conditions of Use