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ECO39: Review, ring-test and guidance for TKTD modelling

Principal Investigator

Dr Roman Ashauer

Environment Department, Wentworth Way, University of York

Heslington,York, YO10 5NG, United Kingdom

Telephone: +44-(0)-1904-324052

E-mail: roman.ashauer@york.ac.uk

Collaborators

Dr Tjalling Jager, DEBtox Research

Description

The additional information and insight gained through the application of toxicokinetic-toxicodynamic (TKTD) modelling can strengthen the environmental risk assessment of chemicals, such as those applied in consumer products or plant protection products (PPPs). For the endpoint survival the most suitable and powerful tool is currently the General Unified Threshold model of Survival (GUTS), which consists of two complimentary models: GUTS-SD (stochastic death) and GUTS-IT (individual tolerance). GUTS has been submitted as part of the environmental risk assessment of PPPs, but it can also be used for purposes of REACH. In order to ease the use of GUTS and increase trust and acceptability we need to compare and test the range of software implementations available and generate guidance on how to use GUTS in Environmental Risk Assessment of chemicals. Beyond the endpoint survival, and beyond GUTS, TKTD models have broader applicability for sub-lethal endpoints, assessment of multiple stressors and reverse dosing for high-throughput toxicity testing. Reviewing the state of the science of TKTD modelling will enable development of a roadmap towards wider use of TKTD models in environmental risk assessment of chemicals in general and highlight synergies and differences with human safety evaluation methods.

 

The objectives of this project are:

1. Review the state of the science of TKTD modelling in general and develop a roadmap towards broader applicability in chemical risk assessment

2. Carry out a ring test of different software implementations of the General Unified Threshold model of Survival (GUTS)

3. Develop guidance on how to use GUTS for environmental risk assessment of chemicals

 

Work Content

WP1: Review the state of the science of TKTD modelling in general and develop a roadmap towards broader applicability in chemical risk assessment

WP2: Carry out a ring test of different software implementations of the General Unified Threshold model of Survival (GUTS)

WP3: Develop guidance on how to use GUTS for environmental risk assessment of pesticides

WP4: Writing of e-book

 

 

Timeline: February 2017 > January 2018

LRI funding: 80.000,00 €

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