Cefic-lri Programme | European Chemical Industry Council

ECO52 – Bioavailability, complex substances and overall persistence (BCOP): three themes to deliver a step-change in persistence assessments

Principal Investigator

Christopher Hughes
Ricardo Energy & Environment
Gemini Building, Fermi Avenue
Harwell, Oxon, OX11 0QR
United Kingdom
chris.hughes@ricardo.com
Tel. +44 1235 753 687

Collaborators

Dr Stefan Hahn, Fraunhofer ITEM, Hannover, DE, stefan.hahn@item.fraunhofer.de

Michael Klein, Fraunhofer IME, Hannover, DE, michael.klein@ime.fraunhofer.de

David Brown, Ricardo Energy & Environment, Oxon, UK, david.brown@ricardo.com

Dieter Hennecke, Fraunhofer IME, Hannover, DE, dieter.hennecke@ime.fraunhofer.de

Judith Klein, Fraunhofer IME, Hannover, DE, judith.klein@ime.fraunhofer.de

Graham Whale, Whale Environmental Consultancy Ltd, UK, grahamwhale58@gmail.com

Description

This project seeks to explore opportunities to improve weight-of-evidence approaches in persistence assessment by incorporating the latest scientific developments in bioavailability, complex substances and overall persistence. A main focus of the project will be to improve guidance for substances outside the applicability domain of existing frameworks, such as UVCBs and polymers. The overall aim of the project is to offer practical guidance that will improve robustness, consistency and predictability of persistence assessments in chemical regulation.

Related Publications

Posters

Hughes, CB, Brown, DM, Griffiths, M, Hahn, S, Hennecke, D, Klein, J, Klein, M, Whale, GF. Complex substances and overall persistence (BCOP): three themes to deliver a step-change in persistence assessments – Overview of a CEFIC-LRI project (ECO52). SETAC Europe SciCon 30th Annual Meeting, May 2020, online.

Publications

Guidance for the Persistence Assessment of UVCB Substances, Chris Hughes, Ricardo Energy & Environment

Guidance for the Persistence Assessment of difficult Test substance, Chris Hughes, Ricardo Energy & Environment

Guidance for the Persistence Assessment of UVCB Substances, Chris Hughes, Ricardo Energy & Environment

WP3A – Modelling Exercises, Judith Klein, Fraunhofer IME

WP3B – Framework on multi-media fate modelling within persistence assessmenet, Michael Klein, Fraunhofer IME

WP4 – Comparison between natural and synthetic polymers, Stefan Hahn, Fraunhofer ITEM

WP5 – Framework to Improve the Use of Weight of Evidence in Persistence Assessments, Chris Hughes, Ricardo Energy & Environment

Final Report – Framework on persistence assessment for Polymers and Microplastics, Dr. Stefan Hahn, Fraunhofer Institute for Toxicology and
Experimental Medicine (ITEM) & Dr. Dieter Hennecke, Fraunhofer Institute for Molecular Biology and Applied Ecology (IME)

Timeline: March 2020 > March 2022

LRI funding: € 231 256

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