The aim of the study is to identify effects caused by endocrine modulation in fish and evaluate these with respect to dysfunction in sex differentiation, development of functional organs as well as fecundity. Another aspect is the determination of the variability of these endpoints, including their seasonality. Finally, the impact of effects, if they exist, will be investigated on a population level.
M Hecker, CR Tyler, M Hoffman, S Maddix, L Karbe, Plasma biomarkers in fish provide evidence for endocrine modulation in the Elbe River, Germany, Environmental Science and Technology 2002, 36, 2311-231.
M Hecker, Natural variability of endocrine functions and their modulation by anthropogenic influences, PhD Thesis, University of Hamburg, 2001.