Prof. Peter Matthlessen and John Fawell MBE, Watts & Crane Associates, UK
The specific objectives of the project are:
– Development of a ”Threshold of Toxicological Concern (TTC)” concept for ecotoxicology that is analogous to the mammalian approach. Potency, environmental fate and exposure to a substance should be considered to establish environmental ”negligible risk” levels.
– Comparison of modes of action covered by, and sensitivity of, proposed test methods for assessing chemical endocrine activity.
– Investigations into control variability of fish reproduction to determine what change is clearly an adverse biological effect.