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EMSG56-BASF: Combined Low-dose Exposures to Anti-androgenic Substances

Principal Investigator

Dr. Steffen Schneider
GV/TA - Z470, Experimental Toxicology and Ecology
67063 Ludwigshafen
Germany
Tel: +49 621 60 58144
Fax: +49 621 60 58134

Collaborators

Dr. Stephanie Melching-Kollmuss, Dr. Roland Buesen, Dr. Hennicke Kamp and Dr. Burkhard Flick, BASF SE, DE
Prof. Dr. Mohamed Benahmed, Bí¢timent Universitaire Archimed, FR

 

Description

Considering the available definitions of endocrine disrupting compounds (Weybridge, 1996 and WHO/IPCS, 2002) it is recommended to follow an appropriate experimental design, duration of exposure, and completeness of relevant endpoints (OECD, 2002). As expected human exposures to chemicals, pesticides, biocides, cosmetic ingredients are far below the NOAELs identified in the animal studies, combination studies reflecting these ranges of exposure could represent relevant bases for regulatory decisions with respect to mixture risk assessments. Even lower doses, corresponding to legally binding reference values (like e.g. ADIs, DNELs, RfC) would be appropriate.

This project is organized in three work packages. The androgen system has been chosen exemplarily for any endocrine system, based on the most comprehensive techniques and analyses already established in the laboratory facilities of the project team.

In addition to the workpackages, BASF is sponsoring the conduct of in-vitro studies which focus on describing the potential of a compound to interfere with the endocrine system by determining their receptor activity as well as interference with the steroidogenesis of androgens. Furthermore, downstream signal pathways of relevant receptors will be investigated.

Related Publications

Presentation:

Endocrine Disruptors: Industry workshop outcomes by Markus Junker

Poster:

Endocrine exposure at environmentally relevant concentrations by Karma C. Fussell, Stephanie Melching-Kollmuss, Sibylle Groeters, Volker Strauss, Benazir Siddeek, Mohamed Benahmed, Markus Frericks, Bennard van Ravenzwaay and Steffen Schneider, presented at the 14th Cefic-LRI Annual Workshop 2012

Investigation of Flutamide at Environmentally Relevant Concentrations by Stephanie Melching-Kollmuß, Steffen Schneider, Karma C. Fussell, Sibylle Groeters, Volker Strauß, Benazir Siddeek, Mohamed Benahmed, Markus Frericks and Bennard van Ravenzwaay

Investigation of Vinclozolin at Environmentally Relevant Concentrations by Sibylle Groeters, Steffen Schneider, Karma C. Fussell, Volker Strauß, Markus Frericks, Stephanie Melching-Kollmuß, Benazir Siddeek, Mohamed Benahmed and Bennard van Ravenzwaay

Endocrine Exposure at Environmentally Relevant Concentrations by Fussell Karma C., Steffen Schneider, Stephanie Melching-Kollmuß, Sibylle Groeters, Volker Strauß, Benazir Siddeek, Mohamed Benahmed, Markus Frericks and Bennard van Ravenzwaay

 

Endocrine exposure at environmentally relevant concentrations by Karma C. Fussell, Stephanie Melching-Kollmuss, Sibylle Groeters, Volker Strauss, Benazir Siddeek, Mohamed Benahmed, Markus Frericks,
Bennard van Ravenzwaay, Steffen Schneider

 

 

 

Timeline: January 2011 > January 2013

LRI funding: €600.000

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