Fax: +31 30 2535077
Dr. Melvin Andersen, The Hamner Institute for Health Sciences, USA
The objectives of this project are the further development of strategies making use of the integration of different areas of knowledge on the chemistry and the biological activity of compounds, and their use in the interpretation of biomonitoring data.
These integrated approaches will include:
An essential element in this project is the use of in vitro data on metabolism, in vitro data on the toxicodynamics and the use of these data in physiologically-based kinetic and dynamic modelling. This would enable a quantification of the risk of exposure to compounds.
Click here to read the project summary.
Bas J. Blaauboer. Integration of metabolic fate, health effects and biokinetics predictions in an in silico-in vitro-in vivo approach in a tiered testing strategy. Cefic-LRI 14th Annual Workshop, November 2012, Brussels, Belgium.
Elton Zvinavashea, Jerry Campbell Jr,Harvey Clewell III, Melvin Andersen and Bas Blaauboer. Integrating In Vitro Kinetic and Toxicity Data in Quantifying In Vivo Risk of Exposure to Compounds. Cefic-LRI 11th Annual Workshop, November 2009, Brussels, Belgium.
Milou M.L. Dingemans, Alina Efremenko, Emiel Rorije, Jos Bessems, Harvey Clewell and Bas J. Blaauboer. Inclusion of metabolism in toxicity predictions comparing in silico with in vivo. Cefic-LRI 13th Annual Workshop, November 2011, Brussels, Belgium.