The objectives of this project are the further development of strategies making use of the integration of different areas of knowledge on the chemistry and the biological activity of compounds, and their use in the interpretation of biomonitoring data.
These integrated approaches will include:
An essential element in this project is the use of in vitro data on metabolism, in vitro data on the toxicodynamics and the use of these data in physiologically-based kinetic and dynamic modelling. This would enable a quantification of the risk of exposure to compounds.
Research project summary:
Data on in vitro metabolism and mechanisms of action in combination with kinetic modeling: integrating in risk assessment by M. Dingemans, B. Blaauboer, A. Efremenko, M. Yoon, J.L. Campbell, H.J. Clewell, E. Rorije, J. Bessems, M. Schriks and W. Brands
Integrating In Vitro Kinetic and Toxicity Data in Quantifying In Vivo Risk of Exposure to Compounds by Elton Zvinavashea, Jerry Campbell Jr,Harvey Clewell III, Melvin Andersen and Bas Blaauboer
Inclusion of metabolism in toxicity predictions comparing in silico with in vivo by Milou M.L. Dingemans, Alina Efremenko, Emiel Rorije, Jos Bessems, Harvey Clewell and Bas J. Blaauboer