The research project will build upon existing technology for estimating dermal penetration of chemicals by addressing unmet needs in a mechanistically-based manner that will not only provide an improved risk assessment tool for the immediate future but also enrich the science in this area to support ongoing developments.
Results of this project will be able to (1) explain and (2) reliably predict chemical bioavailability from dermal exposure for a broad range of chemical classes and formulations.
The project seeks to advance the state of art by:
a) providing a set of virtual probes to build a hypothesis regarding the mechanism of penetration of the chemical of interest and its ability to change SC structure;
b) developing a hierarchical approach for calculation of transport via different pathways to expand the chemical domain in which reliable quantitative predictions can be obtained;
c) addressing formulation effects on skin permeability based on solution thermodynamics and chemical interactions between the SC and the formulation;
d) characterizing the uncertainty of these predictions.
Miller M.A., Jaworska J. and Kasting G.B., “An appendageal model for the transport of hydrophilic compounds across the skin“, presented at Occupational and Environmental Exposures to Skin (OESCC) conference, 19-21/09/2016
Development of a mechanistic framework to assess dermal absorption of chemicals, presented at the 16th Cefic-LRI Annual Workshop 2014