Principal Investigator
Fax: +31-317-419000
Collaborators
Dr Dieter Hennecke, Senior scientist, Fraunhofer IME, Applied Ecology, dieter.hennecke@ime.fraunhofer.de
Description
In order to fully test the NER for its potential ecotoxicity, an evaluation of extracted residues will also be performed. Currently there are no standard methods, except for isolation and testing of each transformation product. An approach that tests the whole extract and applies an effect-driven philosophy3 will be developed. In addition, a suitable microbial bioassay will be identified that quantitatively correlates the bio-accessible fraction with the solvent extraction method.
Further guidance in the use of NER data in risk assessment will also be developed. For example, the selection of appropriate test species and how many trophic levels has not yet been defined. Also, relating the exposure concentration to the observed effects in extracts (with uncharacterised transformation products) would need to be considered.
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Related Publications
Publications:
Ortega-Calvo JJ, Harmsen J, Parsons JR, Semple KT, Aitken MD, Ajao C, Eadsforth C, Galay-Burgos M, Naidu R, Oliver R, Peijnenburg WJ, Römbke J, Streck G, Versonnen B. From Bioavailability Science to Regulation of Organic Chemicals. Environ Sci Technol. 2015 Sep 1;49(17):10255-64.
Presentations:
Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer. Advances in the Development of Procedures to Establish the Toxicity of Non-Extractable Residues (NER) in soil. SETAC Europe 27th Annual Meeting, May 2017, Brussels, Belgium.
Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer. Risk assessment of Non-Extractable Residues (NER) in soil. AquaConSoil, June 2017, Lyon, France.
Kerstin Dertz, Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer. The development of procedures to establish the toxicity of non-extractable residues (NER) in soil. 9th International Workshop on Chemical Bioavailability in the Terrestrial Environment, November 2017, Warsaw, Poland.
Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer. The development of procedures to establish the toxicity of non-extractable residues (NER) in soil. Cefic-LRI 19th Annual Workshop, November 2017, Brussels, Belgium.
Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer. The development of procedures to establish the toxicity of non-extractable residues (NER) in soil. SETAC Europe 28th Annual Meeting, May 2018, Rome, Italy.
Posters:
Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer. Development of Soup Tests for the Risk assessment of NER in Soil. Cefic-LRI 16th Annual Workshop, November 2014, Brussels, Belgium.
Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer. Development of Soup Tests for the Risk assessment of NER in Soil. SETAC Europe 25th Annual Meeting, May 2015, Barcelona, Spain.
Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer. Risk Assessment of Soils containing Non-Extractable Residues (NER). SETAC Europe 26th Annual Meeting, May 2016, Nantes, France.
Joop Harmsen, Dieter Hennecke, Kerstin Hund-Rinke, Joost Lahr, John Deneer, Bruno Hubesch, Malyka Galay-Burgos, Charles Eadsforth, Chris Finnegan, Gary Roberts, Gordon Sanders. Advances in the Development of Procedures to Establish the Toxicity of Non-Extractable Residues (NER). 7th SETAC World Congress/SETAC North America 37th Annual Meeting, December 2016, Orlando, Florida, USA.
