Cefic-lri Programme | European Chemical Industry Council

Projects

ECO3A.2-USTO: Creation, Evaluation and Application of an Integrated Environmental Fate and Human Food Chain Bioaccumulation Model for Polar and Non-polar Organic Substances (IMPS)

The goals of the project are: To create a mechanistically based, non-steady state, chemical fate and bioaccumulation model to predict wildlife and human exposure to organic chemicals. To further develop this model to make it applicable to polar chemicals that […]

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ECO8: Development of a strategy to predict acute fish lethality using fish cell lines and fish embryos

It is the goal of this research project to investigate if in vitro approaches based on fish cell lines and/or fish embryos can be improved to be widely accepted as an alternative to the acute fish test. With regard to […]

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B3.3: The Intake Fraction (iF) concept: modelling, expansion and application tests

In order to help correlate the exposure of a population to a toxicant directly to the source of exposure, researchers have developed a concept called the intake fraction (iF), which is a dimensionless variable. The estimation of the iF relationship […]

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EMSG42: Increase of the robustness of the fish endocrine assay and avoidance of irrelevant endpoints

The objective of this study was to determine the influence of the test items potassium permanganate, 2-methoxyethanol and octanol to reproduction and the endocrine system of fathead minnow (Pimephales promelas). For this purpose, mature male and female fathead minnow were exposed in […]

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EMSG38: Review of the Relative Contribution of Industrial Chemicals, Compared to Steroids, in Causing the Sexual Disruption in Wild Fish Populations

Steroidal estrogens, originating principally from human excretion, are likely to play a major role in causing widespread endocrine disruption in wild populations of the roach (Rutilus rutilus), a common cyprinid fish, in rivers contaminated by treated sewage effluents. Given the […]

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21DAY: Phase 3 of the validation of the OECD Fish Screening Assay

The eight studies in the attached report were conducted as part of OECD Test Guideline program to validate a standardized OECD protocol for a 21-day fish screening assay for the detection of endocrine active substances (i.e. estrogen, aromatase inhibitors, androgen). […]

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