Projects
ART-TNO: Phase 1: mechanistic model and Bayesian update
Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]
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ECO9-VUA: Relationships between BCF, BMF and BAF: Improving forecasting of residues in biota in the environment based on laboratory testing
Objectives Overview Identify the key properties and parameters impacting bioconcentration factor (BCF) measurements in the laboratory and those impacting field bioaccumulation factor (BAF) assessments. Select a test set of chemicals which include high production volume (HPV) substances in the […]
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EMSG39-BAHE: Assessment of biological variability in mice – Development of a draft protocol
The objectives of this project ar the following: Literature search on biological variability and evaluation with regard to organ weights, cylcicity, sperm parameters Drafting of pre- and main study for the assessment of biological variability
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Q2-MN: Overcoming current Limitations In Metabolism Prediction of Industrial Chemicals (OLIMPIC)
It is foreseen that the assessment of hazard and risk of chemicals under the REACH legislation is assisted by the application of computational methods. In vivo toxicity intrinsically reflects metabolism. Consequently, risk assessment can not neglect metabolism of chemicals. Hence, […]
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EMSG52-MRC: Steroidogenesis and inter species comparison literature review
Masculinisation depends on adequate production of testosterone by the fetal testis within a specific'male programming window'. Disorders resulting from subtle deficiencies in this process are common in humans and environmental exposures/lifestyle could contribute causally as common therapeutic and environmental compounds […]
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EMSG49-CNRS: Reprogramming of DNA methylation during mammalian development and environmental impact of Endocrine Disruptors
The analysis of epigenetic modifications at the level of the genome is a very promising field of research. The major question to be addressed is how the epigenome distinguishes cell types and how epigenetic variability between individuals reflects the influence […]
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EMSG43: Endocrine disrupting effects in fish induced by parasites
Recently evidence evolved that environmental compounds can interfere with the endocrine systems of wildlife and humans. Surface waters are suggested to be the main sink for these so called endocrine disruptors (ED). Therefore aquatic species seem to be the main […]
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EMSG47-WCA: Support a tiered approach to evaluate endocrine effects in aquatic organisms
The specific objectives of the project are: - Development of a ”Threshold of Toxicological Concern (TTC)” concept for ecotoxicology that is analogous to the mammalian approach. Potency, environmental fate and exposure to a substance should be considered to establish environmental […]
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C2.2-HPAG: Description of the nature of the accidental misuse of chemicals and chemical products
The overall objective of this research project is: - To describe the nature of accidental misuse of chemicals and chemical products available to consumers and to put this information in the context of overall estimates of accidental injury from chemicals. […]
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EMSG37-BAYER: Participation of Bayer CropScience in Phase 1A and 1B of the OECD validation work on the “Non-Spawning Fish Screening Assay†for the detection of endocrine active substances according to the OECD test protocol (ENV/JM/TG/EDTA(2002)5)
In a 21-day-assay (phase 1 B), sexually mature female and male fathead minnows (Pimephales promelas) were exposed to a weak estrogen agonist, or a weak aromatase inhibitor, under flow-through conditions. Three different test-compound concentrations, a water-only control, and a corresponding positive control […]
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