EMSG17: Identification of Biomedical Endpoints of Oestrogen Action in the Male Rat With Possible Confirmation in Primate Model and in Man
The objective of the project was to identify biochemical endpoints of oestrogen action in the male rat during foetal and neonatal development, which may have potential for monitoring the level of "oestrogen" exposure of individual animals, either in infancy or […]
EMSG16: Epidemiological Studies of Endocrine Disruptors and Human Health
Hypospadias is a male birth defect in which the urethral orifice is abnormally located on the ventral side of the penis. In western countries, the prevalence of hypospadias varies from 2 to 8 cases per 1000 live births. An increase […]
EMSG12: Exposure to Endocrine-Disruptor Chemicals Assessed by Ligand-Receptor Interaction Analysis of Human Body Fluids
The objective of the research was to determine whether the levels of binding between oestrogenic chemicals and pure oestrogen receptor could be quantified in vitro using ligand receptor interaction analysis. The hope was that such technology might be usefully applied […]
EMSG11: Sperm Quality Studies Measuring Seminiferous Tubules
The objective of this investigation is to use of histopathological/morphometric techniques to assess whether or not there have been changes in morphology of the human testis over the past 50 years.
EMSG10: Do Industrial Oestrogens or Their Metabolites Influence Male Reproductive Function?
The objective of the study was to investigate if alkylphenols, which had been shown to bind to oestrogen receptors, might also influence the catabolism and bioavailablity of natural oestrogens by acting as substrates and/or inhibitors of phenolsulphotransferase activity. The results […]
EMSG9: Development of a Sensitive Assay for Androgenic Activity Using Prostate Cells Lines
The objective of the project is to develop an in vitro assay for androgenic activity based on the use of prostate cell lines. This involves testing and validation of the cell line LNCaP, which is sensitive to weak androgens, anti-androgens, […]
EMSG8: Are Connexins, the Gap Junctional Integral Proteins, Involved in Male Reproductive Disorders Associated With Possible Exposure to Endocrine Disrupting Agents?
The objective of the project is to verify whether impairment of expression and/or function of the gap junctional connexins (elements of the gap junction structure; this structure facilitates "communication" between cells) could be implicated in human male reproductive disorders. An […]
EMSG29: Examination of Bull Sperm as a Sentinel Species for Male Reproductive Health
Discussions over possible declines in male sperm counts are hampered by the lack of human data. Data is readily available, however, on sperm counts from other mammals, and this can provide helpful insight to questions regarding male fertility rates. This […]
EMSG36: Further Development and Scientific Evaluation of Appropriate Methods for Identification and Characterisation of Toxic Effects of Hormonally Active Substances on Reproduction in Birds as Part of Multi-Generation-Studies
The effects of so-called ”endocrine disruptors” (EDs), i.e. hormone-like acting substances of natural or anthropogenic origin or compounds disturbing the endocrine system by other mechanisms, on reproduction are subject to extensive discussion worldwide. For better identification of such effects, regulatory […]
EMSG28: Development, Validation and Application of in Vitro and in Vivo Test Systems for Non-Oestrogenic Endocrine Disrupting Chemicals in Wildlife
The project will provide information on effective in vitro (T-screen & Keratonisation Assay) and in vivo assays (metamorphosis, migration and prolonged FETAX-assay) for alterations of thyroid and retinoid dependent processes. It will bridge the gap between the in vitro and […]