Projects
B2.1-TNO: Characterisation of Uncertainty and Variation in Assessment of Chronic Occupational Exposure
Many adverse health effects of chemical exposure occur after repeated contact over long periods. In assessing the risks of such chronic effects in the workplace, "reasonable worst case" estimates of exposure during a shift or working day are often used. […]
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B2.2-FoBiG: Provide Examples Where Risk Characterisations can be Conducted With the Existing and Possible Inadequate Data Sets
This project will evaluate the estimates used today by several organisations (e.g. U.S.-EPA, WHO, EU) to assess the human health risks of chemical exposure, which result in the derivation of human limit values such as acceptable daily intake, reference doses […]
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B2.3-IOM: Variability and Uncertainty in Chemical Exposures for Regulatory Risk Assessment
The aim of this project is to investigate how the variability and uncertainty of occupational inhalation exposure information may be better incorporated into the European regulatory risk assessment process. In this proposal, we have chosen to focus specifically on inhalation […]
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EEM1-ASTRA: Identification and Evaluation of Emission Databases in Europe
Estimating how much of a particular chemical is released to the environment is key to assessing likely levels of exposure and risk to humans and the environment. Such estimates are often based on very general information due to a lack […]
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EEM4: Development of Tools for Probabilistic Uncertainty Analysis in Environmental Risk Assessment of Chemicals
The risk to wildlife or the environment posed by a given chemical depends on whether its environmental concentration is greater than set quality objectives (the risk quotient). Both environmental concentrations and quality objectives are calculated based on chance (probability), a […]
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EMSG21: Endocrine Disruption in the Marine Environment (EDMAR)
The EDMAR programme is investigating whether there is evidence of changes in the reproductive health of marine life and if so, seeks to identify possible causes and potential impacts. Areas for research include: development of methods for the detection of […]
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EMSG22: Endocrine Disruption in the Aquatic Environment; Laboratory Investigation of Endocrine-Active Chemicals
Laboratory studies are being conducted in which fish are exposed to defined concentrations of known chemicals. Natural steroids, synthetic steroids and xenoestrogens will be assessed. The choice of test chemicals will depend on field studies in the UK and Germany, […]
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EMSG23: Endocrine Modulating Effects in Fish Along the Elbe River and in Reference Areas. Assessment of Risks Related to the Habitat Conditions and the Natural Variability of Endocrine Functions
The aim of the study is to identify effects caused by endocrine modulation in fish and evaluate these with respect to dysfunction in sex differentiation, development of functional organs as well as fecundity. Another aspect is the determination of the […]
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EMSG27: Environmental Effects on Uterine Tissues of Baltic Seals With Special Emphasis on Organochlorines and Uterine Leiomyomas
The study investigated whether leiomyomas in grey seals, collected during the period of decreased levels of organo-chlorines, were in a regressive phase; and whether the period of increased levels of organo-chlorines caused the leiomyomas to proliferate. In addition, in vitro […]
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EMSG28: Development, Validation and Application of in Vitro and in Vivo Test Systems for Non-Oestrogenic Endocrine Disrupting Chemicals in Wildlife
The project will provide information on effective in vitro (T-screen & Keratonisation Assay) and in vivo assays (metamorphosis, migration and prolonged FETAX-assay) for alterations of thyroid and retinoid dependent processes. It will bridge the gap between the in vitro and […]
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