Cefic-lri Programme | European Chemical Industry Council

Projects

IRTA2-001-TNOV: Characterisation of Respiratory Tract Sensitization to Improve Hazard Identification of Respiratory Allergens

This project aimed to improve hazard identification of respiratory chemical allergens, as is presently being done by measuring proliferation and cytokine production in local lymph nodes and IgE in serum upon dermal application of the chemical in question. To this […]

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IRTA2-001-SYNG: Transcript Profiling and Cytokine Fingerprinting : Identification and Characterisation of Chemical Respiratory Allergens

Allergic hypersensitivity of the respiratory tract is an important occupational health problem. A major constraint in the development of appropriate methods for the prospective identification of chemical respiratory allergens is the continuing uncertainty regarding the immunobiological mechanisms of this disease […]

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R2-BIHH: The Physiological and Bronchial Inflammatory Marker Response to Exposure in the Workplace in Patients With Occupational Asthma

Occupational asthma is the commonest occupational lung disease, accounting for 5% of all cases of asthma, and incidence is rising. Sufferers lose on average half their total take-home income (including compensation) for four years after diagnosis. Whilst the clinical and […]

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R2-TNO: The Role of Irritancy and Irritant-Induced Inflammation in the Elicitation of Respiratory Hypersensitivity Reactions

A range of low molecular weight chemicals can cause adverse reactions in the airways such as allergic asthma, including occupational asthma. Allergies involve a generally symptom-free induction phase where sensitisation is induced, and an elicitation (challenge) phase, where inhalation of […]

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IA4.6: A Rat IGE Test for the Identification of Chemical Respiratory Allergens

Some chemicals can induce allergies, including allergy of the lungs and other parts of the respiratory tract. (Examples include acid anhydrides, certain diisocyanates, some platinum salts, certain reactive dyes and plicatic acid). This is an important occupational health problem because […]

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D1.1-NOFE: Biomarkers of Exposure – Trends and Key Developments

The aim of the study was to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study encompassed […]

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C1.6: Possibilities and capabilities of 3D-body-scanning systems for the purpose of risk assessment.

The result of this study shows that a vast pool of data is available from the many kinds of measurement surveys that have been carried out using 3D body scanner technology. However, to evaluate the data or to derive the […]

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A2.3: International Workshop on Methods to Determine Dermal Permeation for Human Risk Assessment

This Workshop was designed to bring together relevant expertise and to reach a consensus recommendation on a standardised protocol for in vitro determination of permeability coefficients. The proposed protocol is intended, in the first instance, for testing aqueous soluble chemicals […]

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D2.1-MRCI: Background Incidence of Key Biomarkers of Chemical Exposure within the General Population

The science of biomarkers and measurement of exposures via biomarkers has progressed substantially in the past ten years, resulting in several occupational exposure limits being set on the basis of biomarker measurement, and the acceptance of biomarkers as measurement of […]

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D1.1-SYNG: Study of the Role and Application of Biomarkers in the Management of the Health Risks Associated with Occupational Exposures to Chemicals

The objective of this project was to provide a concise and impartial view of the major developments in academic, institutional and industrial laboratories in Europe, USA and elsewhere working on biomarkers for monitoring human exposure to chemicals. The research into […]

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