C4 – Transcriptomics bioinformatics best practices in toxicogenomics for regulatory application
This project proposal aims to regroup toxicogenomics experts to test and further develop a regulatory ODAF (R-ODAF) proposal for the toxicogenomics community with the ambition to enable the regulatory bodies to consider omics as a relevant data type to support […]
ECO44 – A toxicokinetic mammalian modelling framework for bioaccumulation assessment
The general objective of this project is to build a toxicokinetic (TK) modelling framework for mammals and develop and integrate various data streams for mammalian B assessment. This research will expand the development, evaluation, and application of the CEFIC-LRI funded […]
B15.2: Development of an integrated risk management measure library
REACH and other European legislation require that companies demonstrate the safe use and control of hazardous substances. For this purpose, the quantitative efficiency of Risk Management Measures (RMM) is required to evaluate the operational conditions (OCs) that are part of […]
B20 – Experimental assessment of inhalation and dermal exposure to chemicals during industrial and professional activities
The purpose of this project is to generate inhalation and dermal exposure data that can be used to evaluate ECETOC TRA worker exposure estimates for key industrial and professional uses of chemicals for PROCs where in previous validation studies the […]
ECO42: Fate-directed toxicity testing and risk assessment of UVCBs
The objectives of this project are (1) to develop and test new approaches for fate-directed ecotoxicity assessment of UVCBs based on new combinations of analytical methods, dosing methods, fate directed fractionation, toxicity testing and models, (2) to conduct a case […]
ECO43: Improving sediment toxicity testing design and data interpretation for very hydrophobic substances
The general objective of the proposed research is to improve sediment toxicity testing design, performance, and data interpretation for VHOCs and to develop guidance in order to maximize realism and value of future testing and thereby to support product and […]
ECO41: Enhanced Screening Methods to Determine Bioaccumulation Potential of Chemicals in Air-Breathing Species
This project plans to develop an approach for assessing bioaccumulation of neutral hydrophobic organic chemicals in air-breathing species based on physical chemical properties (i.e. KOW and KOA) and in-vitro biotransformation bioassay data using mammalian liver S9 in vitro bioassays.
ECO45: Chemicals – Assessment of Risks to Ecosystem Services (CARES) II
This project aims to evaluate the practical applicability of an ecosystem services approach to prospective and retrospective chemical risk assessment.
ECO38: Cross-validation for improving determinations of water solubility for difficult to test substances
Water solubility is a fundamental parameter for the environmental risk assessment of organic chemicals. It is critical for understanding and predicting the environmental fate of substances, and also has relevance for their effect assessment. While water solubility is relatively easy […]
ECO40: Investigations on the bioconcentrations of xenobiotics in the freshwater amphipod Hyalella Azteca and inter-laboratory comparison of a new BCF test protocol.
The identification and scientific assessment of compounds that bioaccumulate in organisms and biomagnify in food webs are important aspects in the regulation of chemicals in several jurisdictions, such as Regulation (EC) No 1107/2009, the Regulation on classification, labelling and packaging […]