Computer models are increasingly used to simulate the behaviour of chemicals in the environment. Based on data on a chemical's properties, release rates and environmental characteristics, these programmes - known as multimedia fate and transport models (MFTM) predict concentrations in […]
To evaluate the persistency of the selected model compounds in the environmental matrices air, water, soil and sediment. Reaction mechanisms and degradation pathways of the model compounds are studied. A theoretical approach will be made to arrive at the conceptual […]
Estimating how much of a particular chemical is released to the environment is key to assessing likely levels of exposure and risk to humans and the environment. Such estimates are often based on very general information due to a lack […]
The risk to wildlife or the environment posed by a given chemical depends on whether its environmental concentration is greater than set quality objectives (the risk quotient). Both environmental concentrations and quality objectives are calculated based on chance (probability), a […]
The EDMAR programme is investigating whether there is evidence of changes in the reproductive health of marine life and if so, seeks to identify possible causes and potential impacts. Areas for research include: development of methods for the detection of […]
Laboratory studies are being conducted in which fish are exposed to defined concentrations of known chemicals. Natural steroids, synthetic steroids and xenoestrogens will be assessed. The choice of test chemicals will depend on field studies in the UK and Germany, […]
The aim of the study is to identify effects caused by endocrine modulation in fish and evaluate these with respect to dysfunction in sex differentiation, development of functional organs as well as fecundity. Another aspect is the determination of the […]
The study investigated whether leiomyomas in grey seals, collected during the period of decreased levels of organo-chlorines, were in a regressive phase; and whether the period of increased levels of organo-chlorines caused the leiomyomas to proliferate. In addition, in vitro […]
The project will provide information on effective in vitro (T-screen & Keratonisation Assay) and in vivo assays (metamorphosis, migration and prolonged FETAX-assay) for alterations of thyroid and retinoid dependent processes. It will bridge the gap between the in vitro and […]
The effects of so-called ”endocrine disruptors” (EDs), i.e. hormone-like acting substances of natural or anthropogenic origin or compounds disturbing the endocrine system by other mechanisms, on reproduction are subject to extensive discussion worldwide. For better identification of such effects, regulatory […]
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