The general objectives of this proposed research are (a) to link the toxicity of chemicals to their chemical activity, (b) to expand and critically evaluate the applicability domain of chemical activity for interpreting toxicity data, and (c) to facilitate the […]
Persistence in the environment is a key property in assessing the environmental risks of organic chemicals. Currently, persistence is most often determined using screening tests such as the OECD ready biodegradability tests and sometimes with simulation tests designed to model […]
Aim: To facilitate engagement of the chemical industry, academia and regulators to help develop and evaluate the ecosystem service approach in guiding risk assessment schemes for any type of xenobiotic chemical. Objectives: Review and evaluate state of knowledge and available […]
Measurement of ocular irritancy is a necessary step in the safety evaluation of both industrial and consumer products. Assessment of the acute eye irritation potential is therefore part of the international regulatory requirements for testing of chemicals. This project will: […]
In the field of ecotoxicolgy the quantification of differences in species susceptibility to toxic substances is mainly estimated using statistical approaches. Although these approaches are very useful for use in Environmental Risk Assessment, they aim at quantifying the variation in […]
To accomplish international recognition of the RTgill-W1 cell line assay for predicting acute toxicity to fish, the project aims to initiate a round-robin trial in order to test the robustness of the established methodology. In particular, the team aims to evaluate the […]
Since the publication of the OECD AOP for skin sensitisation in 2012, there have been even greater efforts to anchor the development and evaluation of new in vitro and in chemico assays to key events within the AOP. Much of […]
Volatile organic compounds (VOCs) are ubiquitous in indoor air and their origin is a plethora of various emission sources including building related materials, furniture, equipment and consumer and household related products. Currently, there is international recognition of the contribution of […]
Environmental exposures during fetal and early life may contribute to complex disease later in life such as allergic diseases (AD), neurodegenerative diseases and cancer. The underlying mechanisms are still undiscovered, but changes in the epigenetic regulation of gene expression (such […]
ECO11: Towards rationally designed hazard, risk and persistency assessment: Putting the “bio” back into biodegradability tests The objectives of this project are as follows: Objective 1a. Determine the extent and variation in microbial diversity of environmental sources used in biodegradation […]
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