Cefic-lri Programme | European Chemical Industry Council

Projects

B10-ICL: Animal and human NOAELS: cross-species comparison, inference and synthesis

The overall aim of the proposed project is to provide a systematic and quantifiable comparison of NOAELs derived from animal studies with those from human studies for a range of chemicals and to develop robust evidence synthesis (meta-analytical) methodology combining […]

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ECO18-Eawag: Improved strategy to assess chemical persistence at the water-sediment interface

In this project, we therefore intend to investigate two hypotheses that should (i) help to better understand the value and information content of the existing OECD 308 protocol, and (ii) help to develop an improved test strategy for assessing persistence […]

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HBM4-VITO:Understanding inter- and intra-individual variability in HBM spot samples

In many large-scale human biomonitoring (HBM) surveys, single samples of blood, urine or other bodily matrices are collected from large numbers of individuals recruited from the general population. These HBM surveys aim to obtain information on the distribution of exposures […]

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B9-VITO: DRESS – DeRmal Exposure aSsessment Strategies

The use of chemicals in consumer products has been, and still is, of great societal importance. Their use allowed industry to achieve a high level of innovation, as well as greatly improve the quality of day-to-day life of many consumers. […]

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EMSG56-BASF: Combined Low-dose Exposures to Anti-androgenic Substances

Considering the available definitions of endocrine disrupting compounds (Weybridge, 1996 and WHO/IPCS, 2002) it is recommended to follow an appropriate experimental design, duration of exposure, and completeness of relevant endpoints (OECD, 2002). As expected human exposures to chemicals, pesticides, biocides, […]

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EMSG55-CEFAS: Critical evaluation of individual and combined natural and synthetic endocrine active compounds in fish: an in vitro & in vivo approach

The overall goal of this project is to characterize the potential in vitro and in vivo activities of plant-derived endocrine active compounds (EACs) versus synthetic substances and to evaluate potential combinatory effects of relevance to fish reproductive health. In particular, the […]

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AIMT2-TNO: Mechanism-based characterisation of systemic toxicity for RepDose database substances employing in vitro toxicogenomics

Many in vitro toxicogenomics initatives so far focus on the overlap between in vitro mechanistic responses and in vivo toxicity, but are primarily concerned with mechanistic studies and hazard identification. Purpose of this study is to extend this towards applications of […]

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ECO17-WAG: Evaluation of test methods for measuring toxicity to sediment organisms

The primary aim of this project is to develop improved methods for assessing potential effects of contaminated sediments on aquatic microorganisms, plants and invertebrates within and across different taxonomic groups, to be applied in a regulatory context such as REACH. The objectives […]

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B8-FRAU: Threshold of Toxicological Concern (TTC) for inhalation exposure: Improvement of the TTC concept for inhalation exposure and derivation of thresholds with the database RepDose

Recent results of the analysis of Cramer classes for inhalation studies indicate that local effects of the respiratory tract and eyes dominate the very low NOEC values in Cramer class 1 and also to some extent in class 3 and […]

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B7-ETHZ: Estimation of realistic consumer exposure to substances from multiple sources and approaches to validation of exposure models

This project will provide a short overview on existing methods for estimating aggregate consumer exposure, i.e. exposure that adds up from consuming different household consumer products, and is built upon the work that is already funded by LRI in response to […]

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