Cefic-lri Programme | European Chemical Industry Council


ECO19-RUG: ChimERA – An integrated modelling tool for ecological risk assessment

The first objective of this project is to couple separate exposure and effect models (here called'sub-models') into a chemical integrated exposure and effect ecosystem model for ecological risk assessment (ChimERA) for the aquatic environment. This will be realized by combining […]

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EMSG57-LAKIND: Endocrine disruptors and obesity, diabetes and heart disease: State of the science and biological plausibility

This project builds on (i) the lessons learned from the recently completed work on methodologic issues affecting epidemiologic research on BPA and (ii) the findings of the project (conducted under Cefic-LRI EMSG54) related to the importance of harmonization of epidemiologic methods for […]

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ECO21-ARC: Improving the performance and expanding the applicability of a mechanistic bioconcentration model for ionogenic organic compounds (IOCs) in fish (BIONIC)

The general objective of this proposed research is to improve the mechanistic understanding of bioaccumulation of ionogenic organic chemicals (IOCs) in aquatic organisms, primarily fish, in the form of mass balance models and to increase the confidence of applying these […]

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ECO20-UA: Development of an alternative testing strategy for the fish early life-stage test for predicting chronic toxicity

The main objective of this project is to use a mechanistic framework to develop and propose a high-throughput tiered-testing strategy for screening and prioritizing chemicals for FELS testing (OECD 210). The main objective can be divided into four parts: 1) […]

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B11-CERTH: Integrated External and Internal Exposure Modelling Platform (INTEGRA)

The objective of INTEGRA is to bring together all available information within a coherent methodological framework for assessing the source-to-dose continuum for the entire life cycle of substances covering an extensive chemical space. Hence, the major component of INTEGRA will […]

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MIAT1,2,3-DOW: A Tender to Develop Case Studies of the Application of the Cefic MIAT Decision Tree Using Monitoring Data from European Studies

This project will support the acceptance of the Cefic MIAT Decision Tree by identifying appropriate monitoring studies of chemicals in the EU and applying the Decision Tree to the data generated by the studies. The goal of this project is […]

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MIAT4-VITO: Assessing the Applicability of the Maximum Cumulative Ratio (MCR): Assessment for Mixtures in Residential Indoor Air Using Monitoring Data from European Studies

The objective of this project is to estimate the relative proportions of the real life exposures to residential indoor air contaminant mixtures in Europe which are (i) of low health concern (ii) of health concern because of the effects of […]

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AIMT3-UM:DECO: Data-integration for Endpoints, Chemoinformatics and Omics

The first objective of this project is to develop a transparent framework that improves the prediction of the repeated dose toxicity of new chemicals by integrating chemoinformatic data with biological information from'omics' and HTS technologies. To create this framework, it […]

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B10-ICL: Animal and human NOAELS: cross-species comparison, inference and synthesis

The overall aim of the proposed project is to provide a systematic and quantifiable comparison of NOAELs derived from animal studies with those from human studies for a range of chemicals and to develop robust evidence synthesis (meta-analytical) methodology combining […]

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ECO18-Eawag: Improved strategy to assess chemical persistence at the water-sediment interface

In this project, we therefore intend to investigate two hypotheses that should (i) help to better understand the value and information content of the existing OECD 308 protocol, and (ii) help to develop an improved test strategy for assessing persistence […]

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