REACH Guidance for Chemical Safety Assessment makes use of mathematical simulation of the retention of chemical substances during waste water treatment. REACH R-16 describes the use of the model SimpleTreat, developed by Struijs and co-workers at RIVM, which simulates the […]
The main objective of this study is to map the state of the art in passive sampling sediments and to investigate which measures we can take to reduce any inter-method and -laboratory variation, in order to increase confidence in the […]
The European Chemical Industry Council has provided funding to Maastricht University for a research project on Research Integrity by exploring one of the most suspected contributors to questionable research practices: selective citation. It is generally accepted that scientific papers should […]
A major hurdle in using chemoinformatic systems is the lack of easily accessible data on substance identity including structures and composition e.g. constituents, impurities and additives as well as high quality, detailed endpoint data of chemical substances. This project is […]
The aim of this project is to establish a framework for tools usable in integrated approaches. For this, efforts in our previous DECO project (CEFIC-LRI AIMT3 grant) will be advanced. DECO focused on the prediction of in vivo repeated dose […]
This project will apply a comprehensive strategy to characterise and curate genome wide methylomes in liver tissues from rats and mouse. This will involve correlation of the profiles generated with public data sets for RNA expression (transcriptomics) and histone modification profiles […]
This project aims to improve the depth and availability of knowledge and understanding of the specific factors affecting the efficiency of risk management measure (RMM) to control human (worker and consumer) and environmental exposures that may result from the use […]
Current practice is that Regulators evaluate the risk from nanoparticles along the whole value chain, from manufacture through application in products to end of life disposal. This project must provide clear input to the evaluation of nanomaterial value chains. Two […]
The project's objective is to develop a systematic evaluation scheme to assess the quality and reliability of the epidemiological evidence for endocrine active substances to exert adverse effects based on an endocrine mode of action. This scheme is then to […]
The objective of this project is to define alerts from (sub)structures of environmental chemicals to predict the formation of non-extractable residues (NER) and their metabolites in soils and sediments. The intention is to provide a computerized tool to predict whether […]
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