Cefic-lri Programme | European Chemical Industry Council

Projects

EMSG34.4-BACR: Continuation of the Hershberger validation with the intact weanling male rat to prove equivalence to the classic castrated male rat version

The current method of assessing the (anti-)androgenic potential of a compound in vivo is through the use of the Hershberger assay.  This involves first castrating adult male rats, allowing the sexual accessory tissues to regress and then exposing the rats […]

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EMSG34.4-SYNG: Evaluation of the weanling and testosterone-stimulateed weanling rat as an alternative to the Hershberger castrated rat in the detection of coded androgens and antiandrogens

Growing concerns regarding the possibility that environmental contaminants could mimic estrogens and androgens and hence disrupt endocrine systems have led to the evaluation of test systems to detect such contaminants. One system, the weanling rat assay, has been suggested as […]

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ECO3A.3-USTO: Evaluation of the predictability and reversibility of environmental accumulation for substances for POP/PBT-like properties

The objectives of these project are: - to gain a quantitative understanding of how chemical and environmental characteristics interact to control long-term time trends of POP/PBT-like substances in various environmental compartments. - to test the ability of current dynamic multimedia models to […]

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ECO6.2-ILSIHESI: Pre-validation of an in vitro fish liver S9 assay to optimize the prediction of bioaccumulation

The specific objectives of this project are to support incorporation of in vitro metabolism data into BCF prediction models and to extrapolate in vitro test results to whole body biotransformation rates (kmet) to be used to refine BCF model predictions. […]

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ECO6.2-CSL: Establishing relationships of biotransformation across organisms

The overall aim of this study is to develop quantitative structure-activity relationships relating to biodegradation, biotransformation and bioaccumulation in organisms from different taxa and trophic levels and to develop relationships between biotransformation in microbial systems, invertebrates and vertebrate species.  This […]

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ART.2-TNO: Advanced REACH Tool – Exposure Database development and population for version 1.5

Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]

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ART-TNO: Phase 1: mechanistic model and Bayesian update

Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]

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ECO9-VUA: Relationships between BCF, BMF and BAF: Improving forecasting of residues in biota in the environment based on laboratory testing

Objectives Overview   Identify the key properties and parameters impacting bioconcentration factor (BCF) measurements in the laboratory and those impacting field bioaccumulation factor (BAF) assessments. Select a test set of chemicals which include high production volume (HPV) substances in the […]

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EMSG39-BAHE: Assessment of biological variability in mice – Development of a draft protocol

The objectives of this project ar the following: Literature search on biological variability and evaluation with regard to organ weights, cylcicity, sperm parameters Drafting of pre- and main study for the assessment of biological variability

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Q2-MN: Overcoming current Limitations In Metabolism Prediction of Industrial Chemicals (OLIMPIC)

It is foreseen that the assessment of hazard and risk of chemicals under the REACH legislation is assisted by the application of computational methods. In vivo toxicity intrinsically reflects metabolism. Consequently, risk assessment can not neglect metabolism of chemicals. Hence, […]

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