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Q2-MN: Overcoming current Limitations In Metabolism Prediction of Industrial Chemicals (OLIMPIC)

Principal Investigator

Dr. Terfloth Lothar
Henkestr. 91
D-91052 Erlangen
Germany
Tel: + 49 9131 815 668
Fax: + 49 9131 815 669

Collaborators

Dr. Robert Finking, BASF SE, Germany
Dr. Eric Fabian, BASF SE, Germany
Dr. Thorsten Bernshausen, (Consultant)

Description

It is foreseen that the assessment of hazard and risk of chemicals under the REACH legislation is assisted by the application of computational methods. In vivo toxicity intrinsically reflects metabolism. Consequently, risk assessment can not neglect metabolism of chemicals. Hence, the need for sophisticated methods for the prediction of metabolism with computational methods arises.This project aims for the improvement of the prediction of metabolism of industrial chemicals in mammals. The holistic investigation will consider in vivo, in vitro and in silico data in order to identify discrepancies between the different methods and to enhance the predictive power of in silico models for metabolism.

Related Publications

Research project summary:

Overcoming current Limitations In Metabolism Prediction of Industrial Chemicals (OLIMPIC) by A.Tarkhov, L. Terfloth, J. Gasteiger, M. Bausen, E. Fabian, R. Finking and T. Bernshausen

Posters:

OLIMPIC - Overcoming current Limitations In Metabolism Prediction of Industrial Chemicals by L. Terfloth, A. Tarkhov, J. Gasteiger, M. Bausen, T. Bernshausen, E. Fabian, R. Finking

OLIMPIC - Overcoming current Limitations In Metabolism Prediction of Industrial Chemicals by L. Terfloth, A. Tarkhov, J. Gasteiger, M. Bausen, T. Bernshausen, E. Fabian, R. Finking and Karin Wiench

OLIMPIC - Overcoming current Limitations In Metabolism Prediction of Industrial Chemicals by L. Terfloth, A. Tarkhov, J. Gasteiger, M. Bausen, E. Fabian, R. Finking and T. Bernshausen

Timeline: January 2009 > December 2010

LRI funding: €150,000

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