The mammalian brain and pituitary gland (hypophysis) are clearly target organs for steroid and thyroid hormone action. There is also evidence that prenatal (in utero) or neonatal (young) exposure to high concentrations of some chemicals can affect the developing nervous system; structural alterations or modifications of behaviour may show up in later life. The aim of this review is to analyse publications, on i) The effects of estradiol, androgens and thyroid hormones in the brain of animals and human; ii) The effects of endocrine active chemicals (EAC), natural and/or man-made in the brain. This review will provide a critical evaluation of data related to reported effects of EAC, especially the reliability and consistency of the data.
Final report and publications expected for 2004.