Cefic-lri Programme | European Chemical Industry Council

Analysis of the Influence of Respiratory Irritation on the Elicitation of Pulmonary Hypersensitivity Reactions and Occupational Asthma

Background

There is clear evidence that a variety of chemicals has the ability to cause allergic sensitisation of the respiratory tract and occupational asthma. Respiratory reactions are provoked in sensitised individuals following inhalation exposure to the inducing allergen. What is not clear is the extent to which pre-existing and/or concurrent respiratory irritation and inflammation will influence the severity and duration of allergen-induced hypersensitivity reactions.
This announcement is a call for proposals for research aimed at defining and characterising the way in which local irritation and inflammation will influence the elicitation of allergic hypersensitivity reactions in the respiratory tract. It is anticipated that a better understanding of the relationship between respiratory irritation and allergic hypersensitivity will permit more accurate assessments of risk to man and improved risk management.

Objectives

Proposals
Proposals submitted for consideration should follow the format of the application from'Application for a CEFIC-LRI Grant' and should address the following areas under individual subheadings:
The title of the research proposal
The name and affiliation of the principal investigator and the laboratory or laboratories in which the work will be conducted
Evidence of the principal investigator's knowledge of, and contributions to, current understanding of respiratory toxicity and allergic hypersensitivity and of the requirements for risk assessment and risk management
A clear definition of the research objectives, including a description of the mechanistic basis for the proposed research
A detailed plan of investigation, including a clearly defined milestone plan which identifies all critical decision points in the research programme
An analysis of how the research programme will be translated into improved approaches to risk assessment and risk management.
Monitoring
The successful applicant(s) will be required to submit a progress report every 6 months during the course of the programme. At the end of the programme, a detailed review of the project and the achievements made will be provided by the principal investigator. The successful applicant or applicants will also be required to prepare for publication a manuscript describing the work undertaken and the results obtained.

Scope

Research proposals should be focused on examination of the interaction between respiratory irritation and allergen-induced hypersensitivity in the pathogenesis of pulmonary disease and occupational asthma. Proposals should demonstrate clearly how a better understanding of such interactions can be translated into improved risk assessment and risk management processes. Proposals will ideally build upon the investigator's experience and current research activities and may identify collaborative and/or inter-disciplinary approaches to address this issue. A three year programme of work is anticipated.

Timing: 3 years

Cost: Estimated maximum of $140,000

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