Cefic-lri Programme | European Chemical Industry Council

Projects

B17: SHINE: Target and non-target Screening of cHemicals in the Indoor enviroNment for human Exposure assessment

The last couple of years have seen substantial efforts expended on the development of sophisticated, high tier modelling of integrated exposure (including via indoor air), such as INTEGRA (developed in a CEFIC LRI project) and Merlin Expo; however these models […]

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B15-UCRAN: Developing a robust method of allocating efficiency measures to regulatory instruments in the chemicals industry

This project aims to improve the depth and availability of knowledge and understanding of the specific factors affecting the efficiency of risk management measure (RMM) to control human (worker and consumer) and environmental exposures that may result from the use […]

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B12-ETHZ: Assessing the relevance of the dust contribution in consumer exposure to substances from consumer products and articles (DustEx)

This project investigates the importance of house dust as a source of human exposure to substances in consumer products and articles. The project will explore the dust pathway in relation to the direct pathways and develop a decision tree as well as […]

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B13-UCIN: Development of a mechanistic in silico multi-scale framework to assess dermal absorption of chemicals

The research project will build upon existing technology for estimating dermal penetration of chemicals by addressing unmet needs in a mechanistically-based manner that will not only provide an improved risk assessment tool for the immediate future but also enrich the […]

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B11-CERTH: Integrated External and Internal Exposure Modelling Platform (INTEGRA)

The objective of INTEGRA is to bring together all available information within a coherent methodological framework for assessing the source-to-dose continuum for the entire life cycle of substances covering an extensive chemical space. Hence, the major component of INTEGRA will […]

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B9-VITO: DRESS – DeRmal Exposure aSsessment Strategies

The use of chemicals in consumer products has been, and still is, of great societal importance. Their use allowed industry to achieve a high level of innovation, as well as greatly improve the quality of day-to-day life of many consumers. […]

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B7-ETHZ: Estimation of realistic consumer exposure to substances from multiple sources and approaches to validation of exposure models

This project will provide a short overview on existing methods for estimating aggregate consumer exposure, i.e. exposure that adds up from consuming different household consumer products, and is built upon the work that is already funded by LRI in response to […]

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B8-FRAU: Threshold of Toxicological Concern (TTC) for inhalation exposure: Improvement of the TTC concept for inhalation exposure and derivation of thresholds with the database RepDose

Recent results of the analysis of Cramer classes for inhalation studies indicate that local effects of the respiratory tract and eyes dominate the very low NOEC values in Cramer class 1 and also to some extent in class 3 and […]

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ART-TNO: Phase 1: mechanistic model and Bayesian update

Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]

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ART.2-TNO: Advanced REACH Tool – Exposure Database development and population for version 1.5

Under REACH, the new chemicals policy in Europe, exposure scenarios form an essential basis for chemical risk assessment reports to show that chemicals can be used safely. This requires a tiered exposure assessment approach in which the first Tier is […]

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