Cefic-lri Programme | European Chemical Industry Council

Projects

B14-RIFM: Skin Sensitisation – Chemical Applicability Domain of the Local Lymph Node Assay (LLNA)

Since the publication of the OECD AOP for skin sensitisation in 2012, there have been even greater efforts to anchor the development and evaluation of new in vitro and in chemico assays to key events within the AOP. Much of […]

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ECO11-UNEW: Towards rationally designed hazard, risk and persistency assessment: Putting the “bio” back into biodegradability tests

The objectives of this project are as follows: Objective 1a.  Determine the extent and variation in microbial diversity of environmental sources used in biodegradation studies i.e. activated sludge, fresh-, estuarine- and marine-waters. Objective 1b.  Examine the relationship between microbial diversity, […]

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ECO10: EPOCH – Evaluation of existing population models for their potential application in ecological risk assessment of chemicals

The objective of the project is to provide a review of population models which can be directly used or which might be modified for the ecological risk assessment of chemicals (ERA). The main focus will be on the aquatic environment […]

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ECO14-USTO: Development and validation of an abbreviated in vivo fish bioconcentration test

The overall objective of the research project is to reduce the cost and the number of animals needed to measure the bioconcentration factor (BCF) of organic chemicals in fish, using the accepted ”gold standard” OECD 305 as the point of reference. […]

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ECO12: Validation Chemicals for Assessing Biodegradation Tests

This project aims to develop a list of reference chemicals covering a range of environmental persistence and non-persistence. This reference set would be available for use to validate modifications to existing biodegradation test methods and to develop new test methods. […]

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ECO15/14-15.2-USTO: Rapid estimation of TMF using laboratory, field and computer modelling methods in aquatic organisms

Chemical bioaccumulation is an interesting scientific phenomenon and an important regulatory consideration. The production and use of chemicals that are assessed as having a high potential to accumulate can be restricted in many jurisdictions.  At the same time, recent scientific […]

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ECO16-IRAS: Generate a validated CBR database and validate a CBR chronic toxicity range for narcotics

The general objective of the research project is to generate greater confidence and acceptance for the application of CBBs in the scientific community and in regulatory contexts. A key element of this research will be to compare model predictions that provide mechanistic […]

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ECO14bis-UNT: Alternative methodology for standard laboratory fish bioconcentration tests

The overall goal of this project is to recommend a scientifically sound and defensible minimalized experimental design for fish bioconcentration measurement.  This experimental design will meet the "spirit" of the OECD 305 protocol producing key regulatory data, but ideally will […]

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ECO3A.2-USTO: Creation, Evaluation and Application of an Integrated Environmental Fate and Human Food Chain Bioaccumulation Model for Polar and Non-polar Organic Substances (IMPS)

The goals of the project are: To create a mechanistically based, non-steady state, chemical fate and bioaccumulation model to predict wildlife and human exposure to organic chemicals. To further develop this model to make it applicable to polar chemicals that […]

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ECO4-RIVO: MonitoringBase. Collation and Evaluation of Monitoring Programmes and Measured Environmental Concentration Data on Organic Chemicals in European Aquatic Environments

To facilitate retrieval of background concentrations and ranges of organic chemical concentrations in the marine and freshwater environment as input for various LRI models (e.g. multi-media, estuary models), ”MonitoringBase” was developed. This database includes information, references and links to more […]

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