Cefic-lri Programme | European Chemical Industry Council

Endocrine Disruption

ECO35: Interference of hepatotoxicity with endocrine activity in fish

The project proposed is driven by the hypothesis that hepatotoxicity may positively or negatively interfere with vitellogenin production, which is used as a key marker of endocrine activity in current OECD test guidelines 229, 230 and 234 and the proposed […]

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EMSG57-LAKIND: Endocrine disruptors and obesity, diabetes and heart disease: State of the science and biological plausibility

This project builds on (i) the lessons learned from the recently completed work on methodologic issues affecting epidemiologic research on BPA and (ii) the findings of the project (conducted under Cefic-LRI EMSG54) related to the importance of harmonization of epidemiologic methods for […]

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EMSG56-BASF: Combined Low-dose Exposures to Anti-androgenic Substances

Considering the available definitions of endocrine disrupting compounds (Weybridge, 1996 and WHO/IPCS, 2002) it is recommended to follow an appropriate experimental design, duration of exposure, and completeness of relevant endpoints (OECD, 2002). As expected human exposures to chemicals, pesticides, biocides, […]

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EMSG39-BAHE: Assessment of biological variability in mice – Development of a draft protocol

The objectives of this project ar the following: Literature search on biological variability and evaluation with regard to organ weights, cylcicity, sperm parameters Drafting of pre- and main study for the assessment of biological variability

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EMSG43: Endocrine disrupting effects in fish induced by parasites

Recently evidence evolved that environmental compounds can interfere with the endocrine systems of wildlife and humans. Surface waters are suggested to be the main sink for these so called endocrine disruptors (ED). Therefore aquatic species seem to be the main […]

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EMSG47-WCA: Support a tiered approach to evaluate endocrine effects in aquatic organisms

The specific objectives of the project are: - Development of a ”Threshold of Toxicological Concern (TTC)” concept for ecotoxicology that is analogous to the mammalian approach. Potency, environmental fate and exposure to a substance should be considered to establish environmental […]

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EMSG37-BAYER: Participation of Bayer CropScience in Phase 1A and 1B of the OECD validation work on the “Non-Spawning Fish Screening Assay” for the detection of endocrine active substances according to the OECD test protocol (ENV/JM/TG/EDTA(2002)5)

In a 21-day-assay (phase 1 B), sexually mature female and male fathead minnows (Pimephales promelas) were exposed to a weak estrogen agonist, or a weak aromatase inhibitor, under flow-through conditions. Three different test-compound concentrations, a water-only control, and a corresponding positive control […]

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EMSG9: Development of a Sensitive Assay for Androgenic Activity Using Prostate Cells Lines

The objective of the project is to develop an in vitro assay for androgenic activity based on the use of prostate cell lines. This involves testing and validation of the cell line LNCaP, which is sensitive to weak androgens, anti-androgens, […]

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EMSG10: Do Industrial Oestrogens or Their Metabolites Influence Male Reproductive Function?

The objective of the study was to investigate if alkylphenols, which had been shown to bind to oestrogen receptors, might also influence the catabolism and bioavailablity of natural oestrogens by acting as substrates and/or inhibitors of phenolsulphotransferase activity. The results […]

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EMSG11: Sperm Quality Studies Measuring Seminiferous Tubules

The objective of this investigation is to use of histopathological/morphometric techniques to assess whether or not there have been changes in morphology of the human testis over the past 50 years.

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