EMSG9: Development of a Sensitive Assay for Androgenic Activity Using Prostate Cells Lines
The objective of the project is to develop an in vitro assay for androgenic activity based on the use of prostate cell lines. This involves testing and validation of the cell line LNCaP, which is sensitive to weak androgens, anti-androgens, […]
EMSG10: Do Industrial Oestrogens or Their Metabolites Influence Male Reproductive Function?
The objective of the study was to investigate if alkylphenols, which had been shown to bind to oestrogen receptors, might also influence the catabolism and bioavailablity of natural oestrogens by acting as substrates and/or inhibitors of phenolsulphotransferase activity. The results […]
EMSG11: Sperm Quality Studies Measuring Seminiferous Tubules
The objective of this investigation is to use of histopathological/morphometric techniques to assess whether or not there have been changes in morphology of the human testis over the past 50 years.
EMSG12: Exposure to Endocrine-Disruptor Chemicals Assessed by Ligand-Receptor Interaction Analysis of Human Body Fluids
The objective of the research was to determine whether the levels of binding between oestrogenic chemicals and pure oestrogen receptor could be quantified in vitro using ligand receptor interaction analysis. The hope was that such technology might be usefully applied […]
EMSG17: Identification of Biomedical Endpoints of Oestrogen Action in the Male Rat With Possible Confirmation in Primate Model and in Man
The objective of the project was to identify biochemical endpoints of oestrogen action in the male rat during foetal and neonatal development, which may have potential for monitoring the level of "oestrogen" exposure of individual animals, either in infancy or […]
RTD-INSERM: Neuroendocrine Effects of Endocrine Active Chemicals (EAC): a Literature Review
The mammalian brain and pituitary gland (hypophysis) are clearly target organs for steroid and thyroid hormone action. There is also evidence that prenatal (in utero) or neonatal (young) exposure to high concentrations of some chemicals can affect the developing nervous […]
EMSG35-BASF: Enhanced OECD TG 407 – Development and Validation
Concerns that toxicological test guidelines may not optimally detect effects on the endocrine system have lead to proposals to enhance the current sub-acute rodent OECD Test Guideline No. 407 (OECD 1995). The efficacy of the modified enhanced (phase 2) protocol […]