Cefic-lri Programme | European Chemical Industry Council

Projects

HBM4-VITO:Understanding inter- and intra-individual variability in HBM spot samples

In many large-scale human biomonitoring (HBM) surveys, single samples of blood, urine or other bodily matrices are collected from large numbers of individuals recruited from the general population. These HBM surveys aim to obtain information on the distribution of exposures […]

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HBM3: Data on in vitro metabolism and mechanisms of action in combination with kinetic modelling: integrating in risk assessment

The objectives of this project are the further development of strategies making use of the integration of different areas of knowledge on the chemistry and the biological activity of compounds, and their use in the interpretation of biomonitoring data. These […]

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HBM2-DOW: Development of a Tiered Set of Modelling Tools for Derivation of Biomonitoring Guidance Values

Current determinations of the exposures that correspond with biomonitoring data (parent/metabolite in blood/urine) are generally conducted with chemical-specific pharmacokinetic models that are physiologically-based (PBPK), to best simulate xenobiotic disposition in complex mammalian systems. While these models are necessary to accurately […]

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HBM2.2-ITC: Development of a computer program with a multi-level modelling tool for the estimation of biomonitoring equivalent guidance values for chemical agents related to health based exposure rates for inhalation, oral intake and/or skin exposure.

Objective: Development of a tiered tool with compartmental and physiologically based toxicokinetic models, taken up in a software program, to derive Biomonitoring Equivalent Guidance Values (BEGV) based on existing health based acceptable daily doses or acceptable health based daily exposures. […]

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HBM1-UCRA: A Framework for the Development and Application of Environmental Biological Monitoring Guidance Values

Biomonitoring is a useful tool to aid the assessment of exposure to many chemical substances but currently our ability to detect hazardous substances (or their metabolites and effects) may often exceed our understanding of the biological relevance of these results. […]

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D2.2-VITO: Generation and Application of a Model to Determine Intra- and Inter-individual Variation in Biomarkers

Biomarkers which reflect levels of pollutants in the human body offer a unique opportunity to investigate impact of environmental pollution on humans. Biomarker levels in the general population are influenced by genetic, physiological and external factors. Knowledge on which factors […]

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D1.1-SYNG: Study of the Role and Application of Biomarkers in the Management of the Health Risks Associated with Occupational Exposures to Chemicals

The objective of this project was to provide a concise and impartial view of the major developments in academic, institutional and industrial laboratories in Europe, USA and elsewhere working on biomarkers for monitoring human exposure to chemicals. The research into […]

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D2.1-MRCI: Background Incidence of Key Biomarkers of Chemical Exposure within the General Population

The science of biomarkers and measurement of exposures via biomarkers has progressed substantially in the past ten years, resulting in several occupational exposure limits being set on the basis of biomarker measurement, and the acceptance of biomarkers as measurement of […]

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D1.1-NOFE: Biomarkers of Exposure Trends and Key Developments

The aim of the study is to evaluate existing biomarkers of exposure to xenobiotics and analytical methods from the point of view of the possibility of practical use for assessing and managing occupational and environmental health risk. The study will […]

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