Projects
IA4.6: A Rat IGE Test for the Identification of Chemical Respiratory Allergens
Some chemicals can induce allergies, including allergy of the lungs and other parts of the respiratory tract. (Examples include acid anhydrides, certain diisocyanates, some platinum salts, certain reactive dyes and plicatic acid). This is an important occupational health problem because […]
Read more
R2-TNO: The Role of Irritancy and Irritant-Induced Inflammation in the Elicitation of Respiratory Hypersensitivity Reactions
A range of low molecular weight chemicals can cause adverse reactions in the airways such as allergic asthma, including occupational asthma. Allergies involve a generally symptom-free induction phase where sensitisation is induced, and an elicitation (challenge) phase, where inhalation of […]
Read more
IRTA2-001-SYNG: Transcript Profiling and Cytokine Fingerprinting : Identification and Characterisation of Chemical Respiratory Allergens
Allergic hypersensitivity of the respiratory tract is an important occupational health problem. A major constraint in the development of appropriate methods for the prospective identification of chemical respiratory allergens is the continuing uncertainty regarding the immunobiological mechanisms of this disease […]
Read more
IRTA2-001-TNOV: Characterisation of Respiratory Tract Sensitization to Improve Hazard Identification of Respiratory Allergens
This project aimed to improve hazard identification of respiratory chemical allergens, as is presently being done by measuring proliferation and cytokine production in local lymph nodes and IgE in serum upon dermal application of the chemical in question. To this […]
Read more
IRTA2-001-VITO: In Vivo and In Vitro Characterisation of Chemical Respiratory Allergens: Development of an In Vitro Assay Using Gene Expression Profiling
The main objective of this project is the development of an approach/strategy that can be used to identify chemical allergens and if possible to discern respiratory from contact sensitizers. In order to accomplish this, the proposed study aims to identify […]
Read more