The widespread adoption and application of physiologically based pharmacokinetic (PBPK) modelling in product development and safety assessment of chemicals has been hampered by criticism that these models are data hungry, resource intensive, complex and require high levels of mathematical expertise and programming skills. The use of PBPK models would be enhanced by the availability of a user-friendly, transparent and independently auditable, free-to-use platform for running models and analysing model structure and output.
To address this need, an application called R-Vis is being developed using the open source syntax, R. The motivation for this tool is to provide an intuitive, freely available modelling platform for biologically based, quantitative safety and risk assessment of chemicals. An important feature will be the prediction of human in vivo doses from alternative-to-animal systems. R-Vis will include a module for this purpose which will deploy the most appropriate statistical techniques for dose reconstruction from human biological monitoring data and alternative-to-animal systems. Such a tool should make this powerful approach more readily accessible to safety toxicologists and risk assessors.
The R-Vis tool will be available in May 2019.
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McNally, K., Cotton, R., Hogg, A., and Loizou, G. (2014) Toxicology 315(0), 70-85.