Human carcinogens may act by different modes of action, but generally can be classified as genotoxic and non-genotoxic. This dataset was developed to identify most sensitive endpoints and/ or point of departures after chronic oral exposure for non-genotoxic carcinogens, within the framework of Cefic LRI project B18.2.
Compounds which were classified as non-genotoxic carcinogens were identified from the CPDB database (as available from the CEFIC LRI B18 project). NOEL values were derived for these compounds from chronic and (if required) subchronic studies following oral application, using well established high quality databases (e.g. RepDose, ToxRefDB, COSMOS or peer-reviewed publications).
The dataset includes NOELs for the most sensitive apical effect in the entire study as well as a description of the data quality and reference to study. The lower benchmark dose levels (BMDL) per compound are given, and EDT10 values were calculated using logistic regression to the proportion of tumour bearing animals with a logit link function.
Access
TTC-NGC will be released in the fall of 2020.
The dataset is freely accessible here.
Questions should be addressed to sylvia.escher@item.fraunhofer.de.
References
Boobis A, Brown P, Cronin MTD, Edwards J, Galli CL, Goodman J, Jacobs A, Kirkland D, Luijten M, Marsaux C, Martin M, Yang C, Hollnagel HMet al., 2017, Origin of the TTC values for compounds that are genotoxic and/or carcinogenic and an approach for their re-evaluation, CRITICAL REVIEWS IN TOXICOLOGY, Vol: 47, Pages: 705-727, ISSN: 1040-8444
