Paternal carcinogen exposures and genetic risks in their offspring
Dr. Roger Godschalk is Assistant Professor at the Department of Health Risk Analysis and Toxicology, of the University of Maastricht. His current studies focus on the use of DNA damage in biomonitoring studies and its relevance in assessing health risks. Dr. Godschalk developed a new methodology for the detection of DNA damage by ethylating compounds, a method which was subsequently successfully applied to human samples. He received an EU Marie-Curie fellowship (2001-2002), and worked at the same institute on the role of DNA damage by lipid peroxidation products in atherosclerosis. He obtained his PhD in genetic toxicology at the University of Maastricht for his work on “Biomarkers for exposure to polycyclic aromatic hydrocarbons”, which was awarded with the Thesis price of NUTRIM (Nutrition and Toxicology Research Institute Maastricht).
Dr. Peter Andras (University of Newcastle, UK)
Dr Peter Andras is a Lecturer in the School of Computing Science of the University of Newcastle (UK). Dr Andras earned his PhD from the Babes-Bolyai University (Cluj, Romania) in the area of mathematical analysis of artificial neural networks. His current research is in the area of information processing in complex systems with a recent focus on the analysis of protein interaction networks. It also includes work on evolution of complex systems and data analysis with machine learning methods.
Vitamin B12 as an analytical tool within toxicological studies
Dr Johanna Haglund is Assistant Professor in the Dept of Environmental Chemistry at Stockholm University, where she focuses on the development of procedures where the supernucleophilic cob(I)alamin is utilised to study reactive chemicals and metabolites, a majority of compounds relevant in industrial, pharmaceutical and background exposures. Dr Haglund earned her PhD from the Department of Genetic and Cellular Toxicology, University of Stockholm (Sweden) for her work on “Supernucleophilic Cob(I)alamin: Analytical Tool for Genotoxic Compounds In Vitro and In Vivo”.
Interactions between polycyclic aromatic hydrocarbon exposure and potential damage to DNA in humans
Dr. Sofia Pavanello teaches Industrial Toxicology at the school of Occupational Medicine at the University of Padova. Dr. Pavanello has been studying the influence of genetic and environmental factors in human exposure to the carcinogenic polyciclic aromatic hydrocarbons (PAHs). Her early efforts were directed towards investigating the biomonitoring of human exposure to PAHs by detection of the damaging DNA adduct formation. Since 1988, her research has concentrated on the detection of PAH-DNA adducts in humans exposed to PAHs. Using different techniques she has demonstrated the relationship between DNA adducts formation and exposure to PAHs. More recently, her interest has been expanded to the study on the genetic polymorphim of enzymes involved on metabolism of PAHs and aromatic amines showing that metabolic polimorhism on genetic basis influence two indicators of genotoxic exposure (urinary mutagenicity and PAH-DNA adducts)