Projects

Intelligent testing

ECO59 : FRAGMENT-MNP: Developing a mechanistic model of Micro and NanoPlastic FRAGMentation in the ENvironmenT

The overarching objective of this project is to develop and deliver a pragmatic open-source mechanistic model of how environmental factors affect plastic fragmentation and degradation rates. The model will be applicable across a range of conditions in multiple environmental compartments. […]

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Intelligent testing

ECO58 : Comprehensive additive release and bioaccessibility model for risk assessment of micro- and nano-plastics in the environment

The ubiquitous occurrence of plastics in natural waters1, 2 is a consequence of vast and increasing utilization of synthetic polymers in commercial, industrial, and consumer applications. While the implications of continuous ecological exposure to plastic particles in the nano- to […]

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Human Health

C10 : A Tiered Strategy to Assess Microplastic Inhalation

The LRI C10 project aims to develop better tools for the identification of the inhalation toxicity of microplastics of different origin/with different properties. Humans are ubiquitously exposed to microplastics; this includes a diverse class of compounds/particles but also very different […]

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Intelligent testing

ECO57 : μPLANET – microPlastic Long-range transport Assessment aNd Estimation Tools

Recent research has highlighted the apparent ubiquity of plastic debris, including Microplastic Particles (MPs), across the planet and particularly in the oceans. The release of MPs to the environment represents a particular concern given their resistance to degradation. The continuous […]

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Intelligent testing

ECO56: UTOPIA: Development of a mUltimedia uniT world OPen-source model for mIcroplAstic

The main objective of UTOPIA is to develop an open-source unit world multimedia modeling platform to synthesize knowledge and understanding about the fate of microplastic in the environment. The UTOPIA project aims to deliver a general purpose open-source modeling platform […]

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Acceptance of technology

AIMT11: Enhancing in vitro DNT Testing Strategy

Recently, the need for developmental neurotoxicity (DNT) testing has been moving into the focus of the scientific community including regulatory scientists. Several initiatives promoted by EFSA, the OECD, and the International STakeholder NETwork (ISTNET) for DNT highlighted the most urgent […]

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Complex environments

ECO54: Developing a tiered modeling framework in support of risk assessment of chemical substances associated with mobility concerns

Persistent, mobile, and toxic (PMT) chemicals, including but not limited to plant protection products, pharmaceuticals, and personal care products, are perceived as an emerging threat to aquatic environments and drinking water quality [1]. Due to their high polarity and water […]

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Human Health

C9: Mining the developmental toxicity genome in the zebrafish embryo test to develop a spatio-temporal map on morphogenesis and associated biomarker.

The LRI C9 project “zet-o-map” aims to develop better tools for the identification of teratogenic compounds. One of the most promising assays is the zebrafish embryo teratogenicity assay (ZETA).

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Intelligent testing

ECO 55: Assessing the Impact of Sample Collection on Microbial Population and Validity Criteria in the OECD 309 Surface Water Mineralisation Test

This project will provide improved guidance on surface water sample collection, storage and treatment including a scientifically defensible maximum range between water source sampling and experimental temperature and a suite of quantitative and qualitative tests that further demonstrate inoculum viability […]

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C8 – Assessing the Repeatability of Metabolomics Within a Regulatory Context Through a Multi-laboratory Ring-trial

Background: Metabolomics has reached a critical point in determining its value to regulatory toxicology. Building on 20 years of metabolomics research in toxicology, during 2018-19 the first metabolomics data in a registration dossier was submitted to ECHA; metabolomics best-practice and […]

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