Projects
ECO58 : Comprehensive additive release and bioaccessibility model for risk assessment of micro- and nano-plastics in the environment
The ubiquitous occurrence of plastics in natural waters1, 2 is a consequence of vast and increasing utilization of synthetic polymers in commercial, industrial, and consumer applications. While the implications of continuous ecological exposure to plastic particles in the nano- to […]
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C10 : A Tiered Strategy to Assess Microplastic Inhalation
The LRI C10 project aims to develop better tools for the identification of the inhalation toxicity of microplastics of different origin/with different properties. Humans are ubiquitously exposed to microplastics; this includes a diverse class of compounds/particles but also very different […]
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ECO57 : μPLANET – microPlastic Long-range transport Assessment aNd Estimation Tools
Recent research has highlighted the apparent ubiquity of plastic debris, including Microplastic Particles (MPs), across the planet and particularly in the oceans. The release of MPs to the environment represents a particular concern given their resistance to degradation. The continuous […]
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ECO56: UTOPIA: Development of a mUltimedia uniT world OPen-source model for mIcroplAstic
The main objective of UTOPIA is to develop an open-source unit world multimedia modeling platform to synthesize knowledge and understanding about the fate of microplastic in the environment. The UTOPIA project aims to deliver a general purpose open-source modeling platform […]
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AIMT11: Enhancing in vitro DNT Testing Strategy
Recently, the need for developmental neurotoxicity (DNT) testing has been moving into the focus of the scientific community including regulatory scientists. Several initiatives promoted by EFSA, the OECD, and the International STakeholder NETwork (ISTNET) for DNT highlighted the most urgent […]
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ECO54: Developing a tiered modeling framework in support of risk assessment of chemical substances associated with mobility concerns
Persistent, mobile, and toxic (PMT) chemicals, including but not limited to plant protection products, pharmaceuticals, and personal care products, are perceived as an emerging threat to aquatic environments and drinking water quality [1]. Due to their high polarity and water […]
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C9: Mining the developmental toxicity genome in the zebrafish embryo test to develop a spatio-temporal map on morphogenesis and associated biomarker.
The LRI C9 project “zet-o-map” aims to develop better tools for the identification of teratogenic compounds. One of the most promising assays is the zebrafish embryo teratogenicity assay (ZETA).
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ECO 55: Assessing the Impact of Sample Collection on Microbial Population and Validity Criteria in the OECD 309 Surface Water Mineralisation Test
This project will provide improved guidance on surface water sample collection, storage and treatment including a scientifically defensible maximum range between water source sampling and experimental temperature and a suite of quantitative and qualitative tests that further demonstrate inoculum viability […]
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C8 – Assessing the Repeatability of Metabolomics Within a Regulatory Context Through a Multi-laboratory Ring-trial
Background: Metabolomics has reached a critical point in determining its value to regulatory toxicology. Building on 20 years of metabolomics research in toxicology, during 2018-19 the first metabolomics data in a registration dossier was submitted to ECHA; metabolomics best-practice and […]
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B23 – Optimizing the benefit of REACH worker exposure assessments: ensuring meaningful health risk communication
The main objective of the project is to provide a substantial contribution to optimisation of information on (safe) use conditions, specifically in REACH.
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