In combining an animal toxicity study with a multi-omics approach and advanced in silico methods for data interpretation, this project will contribute to “New research tools, such as […] genomics, present exciting approaches that have the potential to link information […]
This project proposal aims to regroup toxicogenomics experts to test and further develop a regulatory ODAF (R-ODAF) proposal for the toxicogenomics community with the ambition to enable the regulatory bodies to consider omics as a relevant data type to support […]
The general objective of this project is to build a toxicokinetic (TK) modelling framework for mammals and develop and integrate various data streams for mammalian B assessment. This research will expand the development, evaluation, and application of the CEFIC-LRI funded […]
REACH and other European legislation require that companies demonstrate the safe use and control of hazardous substances. For this purpose, the quantitative efficiency of Risk Management Measures (RMM) is required to evaluate the operational conditions (OCs) that are part of […]
The purpose of this project is to generate inhalation and dermal exposure data that can be used to evaluate ECETOC TRA worker exposure estimates for key industrial and professional uses of chemicals for PROCs where in previous validation studies the […]
The objectives of this project are (1) to develop and test new approaches for fate-directed ecotoxicity assessment of UVCBs based on new combinations of analytical methods, dosing methods, fate directed fractionation, toxicity testing and models, (2) to conduct a case […]
The general objective of the proposed research is to improve sediment toxicity testing design, performance, and data interpretation for VHOCs and to develop guidance in order to maximize realism and value of future testing and thereby to support product and […]
This project plans to develop an approach for assessing bioaccumulation of neutral hydrophobic organic chemicals in air-breathing species based on physical chemical properties (i.e. KOW and KOA) and in-vitro biotransformation bioassay data using mammalian liver S9 in vitro bioassays.
This project aims to evaluate the practical applicability of an ecosystem services approach to prospective and retrospective chemical risk assessment.
Water solubility is a fundamental parameter for the environmental risk assessment of organic chemicals. It is critical for understanding and predicting the environmental fate of substances, and also has relevance for their effect assessment. While water solubility is relatively easy […]
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